Understanding asthma phenotypes, endotypes, and mechanisms of disease

ME Kuruvilla, FEH Lee, GB Lee - Clinical reviews in allergy & immunology, 2019 - Springer
The model of asthma as a single entity has now been replaced by a much more complex
biological network of distinct and interrelating inflammatory pathways. The term asthma is …

Current understanding of asthma pathogenesis and biomarkers

N Habib, MA Pasha, DD Tang - Cells, 2022 - mdpi.com
Asthma is a heterogeneous lung disease with variable phenotypes (clinical presentations)
and distinctive endotypes (mechanisms). Over the last decade, considerable efforts have …

Treatable traits: toward precision medicine of chronic airway diseases

A Agusti, E Bel, M Thomas… - European …, 2016 - Eur Respiratory Soc
Asthma and chronic obstructive pulmonary disease (COPD) are two prevalent chronic
airway diseases that have a high personal and social impact. They likely represent a …

Global, regional, and national burden of allergic disorders and their risk factors in 204 countries and territories, from 1990 to 2019: A systematic analysis for the Global …

YH Shin, J Hwang, R Kwon, SW Lee, MS Kim… - Allergy, 2023 - Wiley Online Library
Background Asthma and atopic dermatitis (AD) are chronic allergic conditions, along with
allergic rhinitis and food allergy and cause high morbidity and mortality both in children and …

What is asthma− COPD overlap syndrome? Towards a consensus definition from a round table discussion

DD Sin, M Miravitlles, DM Mannino… - European …, 2016 - Eur Respiratory Soc
Patients with asthma–chronic obstructive pulmonary disease overlap syndrome (ACOS)
have been largely excluded from pivotal therapeutic trials and, as a result, its treatment …

Why has it taken so long for biological psychiatry to develop clinical tests and what to do about it?

S Kapur, AG Phillips, TR Insel - Molecular psychiatry, 2012 - nature.com
Patients with mental disorders show many biological abnormalities which distinguish them
from normal volunteers; however, few of these have led to tests with clinical utility. Several …

Treatable traits: a new paradigm for 21st century management of chronic airway diseases: Treatable Traits Down Under International Workshop report

VM McDonald, J Fingleton, A Agusti… - European …, 2019 - Eur Respiratory Soc
“Treatable traits” have been proposed as a new paradigm for the management of airway
diseases, particularly complex disease, which aims to apply personalised medicine to each …

[HTML][HTML] Adherence to inhaled therapies, health outcomes and costs in patients with asthma and COPD

MJ Mäkelä, V Backer, M Hedegaard, K Larsson - Respiratory medicine, 2013 - Elsevier
Suboptimal adherence to pharmacological treatment of asthma and chronic obstructive
pulmonary disease (COPD) has adverse effects on disease control and treatment costs. The …

Global burden of allergic bronchopulmonary aspergillosis with asthma and its complication chronic pulmonary aspergillosis in adults

DW Denning, A Pleuvry, DC Cole - Medical mycology, 2013 - academic.oup.com
Allergic bronchopulmonary aspergillosis (ABPA) complicates asthma and may lead to
chronic pulmonary aspergillosis (CPA) yet global burdens of each have never been …

COPD and its comorbidities: impact, measurement and mechanisms

NA Negewo, PG Gibson, VM McDonald - Respirology, 2015 - Wiley Online Library
Chronic obstructive pulmonary disease (COPD) frequently coexists with other conditions
often known as comorbidities. The prevalence of most of the common comorbid conditions …