[HTML][HTML] High-content CRISPR screening
CRISPR screens are a powerful source of biological discovery, enabling the unbiased
interrogation of gene function in a wide range of applications and species. In pooled …
interrogation of gene function in a wide range of applications and species. In pooled …
Directed evolution: methodologies and applications
Directed evolution aims to expedite the natural evolution process of biological molecules
and systems in a test tube through iterative rounds of gene diversifications and library …
and systems in a test tube through iterative rounds of gene diversifications and library …
Soil microbiome engineering for sustainability in a changing environment
Recent advances in microbial ecology and synthetic biology have the potential to mitigate
damage caused by anthropogenic activities that are deleteriously impacting Earth's soil …
damage caused by anthropogenic activities that are deleteriously impacting Earth's soil …
[HTML][HTML] Microbiome engineering: synthetic biology of plant-associated microbiomes in sustainable agriculture
J Ke, B Wang, Y Yoshikuni - Trends in Biotechnology, 2021 - cell.com
To support an ever-increasing population, modern agriculture faces numerous challenges
that pose major threats to global food and energy security. Plant-associated microbes, with …
that pose major threats to global food and energy security. Plant-associated microbes, with …
Targeted, random mutagenesis of plant genes with dual cytosine and adenine base editors
C Li, R Zhang, X Meng, S Chen, Y Zong, C Lu… - Nature …, 2020 - nature.com
Targeted saturation mutagenesis of crop genes could be applied to produce genetic variants
with improved agronomic performance. However, tools for directed evolution of plant genes …
with improved agronomic performance. However, tools for directed evolution of plant genes …
[HTML][HTML] Machine learning for metabolic engineering: A review
Abstract Machine learning provides researchers a unique opportunity to make metabolic
engineering more predictable. In this review, we offer an introduction to this discipline in …
engineering more predictable. In this review, we offer an introduction to this discipline in …
Recent advances in metabolic engineering of Saccharomyces cerevisiae: new tools and their applications
Metabolic engineering aims to develop efficient cell factories by rewiring cellular
metabolism. As one of the most commonly used cell factories, Saccharomyces cerevisiae …
metabolism. As one of the most commonly used cell factories, Saccharomyces cerevisiae …
Systems metabolic engineering strategies: integrating systems and synthetic biology with metabolic engineering
Metabolic engineering allows development of microbial strains efficiently producing
chemicals and materials, but it requires much time, effort, and cost to make the strains …
chemicals and materials, but it requires much time, effort, and cost to make the strains …
[HTML][HTML] Methods and applications of CRISPR-mediated base editing in eukaryotic genomes
The past several years have seen an explosion in development of applications for the
CRISPR-Cas9 system, from efficient genome editing, to high-throughput screening, to …
CRISPR-Cas9 system, from efficient genome editing, to high-throughput screening, to …
Engineering wired life: synthetic biology for electroactive bacteria
LJ Bird, BB Kundu, T Tschirhart, AD Corts… - ACS Synthetic …, 2021 - ACS Publications
Electroactive bacteria produce or consume electrical current by moving electrons to and
from extracellular acceptors and donors. This specialized process, known as extracellular …
from extracellular acceptors and donors. This specialized process, known as extracellular …