Geroscience, the new interdisciplinary field that aims to understand the relationship between
aging and chronic age-related diseases (ARDs) and geriatric syndromes (GSs), is based on …

Alzheimer's disease remains incurable, and the failures of current disease-modifying
strategies for Alzheimer's disease could be attributed to a lack of in vivo models that …

Alzheimer disease (AD) is characterized by the accumulation of amyloid plaques, which are
predominantly composed of amyloid-β peptide. Two principal physiological pathways either …

This review, gathered from diverse sources, shows how our microbiome influences health
and ultimately how well we age. Evidence linking oral bacteria to Alzheimer's disease (AD) …

Neurotrophins, activating the PI3K/Akt signaling pathway, control neuronal survival and
plasticity. Alterations in NGF, BDNF, IGF-1, or insulin signaling are implicated in the …

The excessive accumulation of soluble amyloid peptides (Aβ) plays a crucial role in the
pathogenesis of Alzheimer's disease (AD), particularly in synaptic dysfunction. The role of …

Transgenic (Tg) mouse models of Alzheimer's disease (AD) are used to investigate
mechanisms underlying disease pathology and identify therapeutic strategies. Most Tg AD …

Alzheimer's disease (AD) begins with a deficit of synaptic function and adenosine A 2A
receptors (A 2A R) are mostly located in synapses controlling synaptic plasticity. The over …

The identification of early and stage-specific biomarkers for Alzheimer's disease (AD) is
critical, as the development of disease-modification therapies may depend on the discovery …

Parkinson's disease (PD) is one of the most common neurodegenerative disorders and is
characterized by the loss of dopaminergic neurons in the substantia nigra (SN). Although the …