Cancers are highly complex diseases that are characterized by not only the overgrowth of
malignant cells but also an altered immune response. The inhibition and reprogramming of …

In one decade, immunotherapy based on immune checkpoint blockades (ICBs) has become
a new pillar of cancer treatment following surgery, radiation, chemotherapy, and targeted …

Dendritic cell (DC) vaccines induce specific immune responses that can selectively
eliminate target cells. In recent years, many studies have been conducted to explore DC …

Since the first Immune Checkpoint Inhibitor was developed, tumor immunotherapy has
entered a new era, and the response rate and survival rate of many cancers have also been …

Checkpoint proteins are an integral part of the immune system and are used by the tumor
cells to evade immune response, which helps them grow uncontrollably. By blocking these …

Colorectal cancer (CRC) patients with liver metastases usually obtain less benefit from
immunotherapy, and the underlying mechanisms remain understudied. Here, we identify …

Human endogenous retroviruses (HERVs) comprise about 8.3% of the human genome and
are capable of producing RNA molecules that can be sensed by pattern recognition …

Simple Summary Tumor immune evasion is mediated in large part by the inhibition of anti-
tumor T cell responses. Both the induction of tumor antigen-specific T cells and the activation …

Background and aims The key role of tissue-resident memory T (TRM) cells in the immune
regulation of hepatocellular carcinoma (HCC) has been investigated and reported, but the …

Crohn's disease (CD) is an incurable inflammatory bowel disease due to unclear etiology
and pathogenesis. Accumulating evidences have shown the harmful role of ferroptosis in …