Simple Summary Based on the latest research progresses, application of immune
checkpoint inhibitors (ICIs) has shown promise in treating breast cancer. Moreover, novel …

Abstract Lymphocyte activation gene 3 (LAG-3) is a negative immune checkpoint and a key
regulator of immune homeostasis with multiple biological activities related to T-cell functions …

Backgrounds It has been observed that high levels of enhancer of zeste homolog 2 (EZH2)
expression are associated with unsatisfactory prognoses and can be found in a wide range …

Transfer RNA (tRNA)-derived small RNAs (tsRNAs) are a new type of non-coding RNAs
(ncRNAs) produced by the specific cleavage of precursor or mature tRNAs. tsRNAs are …

Objectives Perform a bibliometric analysis on the role of LAG-3 in the domain of cancer,
elucidate the prevailing areas of research, and visually depict the evolutionary trajectory and …

Crohn's disease (CD) is an incurable inflammatory bowel disease due to unclear etiology
and pathogenesis. Accumulating evidences have shown the harmful role of ferroptosis in …

CD8+ T-cell exhaustion is a state of dysfunction that promotes tumor progression and is
marked by the generation of Slamf6+ progenitor exhausted (Texprog) and Tim-3+ terminally …

A transfer RNA (tRNA)‑derived fragment (tRF) was found to be a new possible biological
marker and target in carcinoma therapy. However, the effect exerted by tRFs on cervical …

Aside from antibodies, peptides show great potential as immune checkpoint inhibitors (ICIs)
due to several advantages, such as better tumor penetration and lower cost. Lymphocyte …

Abstract Background Type 2 diabetes (T2D) is a complex metabolic ailment marked by a
global high prevalence and significant attention in primary healthcare settings due to its …