Hypoxia development in tumor is closely associated with its increased aggressiveness and
strong resistance to therapy, leading to the poor prognosis in several cancer types …

The gastrointestinal tract is a highly proliferative and regenerative tissue. The intestine also
harbors a large and diverse microbial population collectively called the gut microbiome …

ABSTRACT Hypoxia‐Inducible Factor‐1 (HIF‐1) has been largely studied for its role in cell
survival in hypoxic conditions. The regulation of HIF‐1 is a complex process and involves a …

Anemia is very common in patients with inflammatory disorders. Its prevalence is associated
with severity of the underlying disease, and it negatively affects quality of life and cardio …

HIF is a transcriptional complex that plays a central role in mammalian oxygen homeostasis.
Recent studies have defined posttranslational modification by prolyl hydroxylation as a key …

The transcription factor HIF (hypoxia-inducible factor) has a central role in oxygen
homeostasis in animals ranging from nematode worms to man. Recent studies have shown …

Many patients with cancer suffer from anemia, depression, and an impaired quality of life
(QoL). These patients often also show decreased plasma tryptophan levels and increased …

Hypoxia-inducible factor 1 (HIF-1) is an oxygen-regulated transcriptional activator that plays
essential roles in mammalian development, physiology and disease pathogenesis. The HIF …

Nitric oxide (NO) and nitric oxide synthases are ubiquitous in malignant tumours and are
known to exert both pro-and anti-tumour effects. We summarize our current understanding of …

Hypoxia and free radicals, such as reactive oxygen and nitrogen species, can alter the
function and/or activity of the transcription factor hypoxia-inducible factor 1 (HIF1). Interplay …