Chemical design and synthesis of functionalized probes for imaging and treating tumor hypoxia
Hypoxia development in tumor is closely associated with its increased aggressiveness and
strong resistance to therapy, leading to the poor prognosis in several cancer types …
strong resistance to therapy, leading to the poor prognosis in several cancer types …
Oxygen battle in the gut: Hypoxia and hypoxia-inducible factors in metabolic and inflammatory responses in the intestine
The gastrointestinal tract is a highly proliferative and regenerative tissue. The intestine also
harbors a large and diverse microbial population collectively called the gut microbiome …
harbors a large and diverse microbial population collectively called the gut microbiome …
Regulation of hypoxia‐inducible factor‐1a by reactive oxygen species: new developments in an old debate
S Movafagh, S Crook, K Vo - Journal of cellular biochemistry, 2015 - Wiley Online Library
ABSTRACT Hypoxia‐Inducible Factor‐1 (HIF‐1) has been largely studied for its role in cell
survival in hypoxic conditions. The regulation of HIF‐1 is a complex process and involves a …
survival in hypoxic conditions. The regulation of HIF‐1 is a complex process and involves a …
Physiology and inflammation driven pathophysiology of iron homeostasis—mechanistic insights into anemia of inflammation and its treatment
L Lanser, D Fuchs, K Kurz, G Weiss - Nutrients, 2021 - mdpi.com
Anemia is very common in patients with inflammatory disorders. Its prevalence is associated
with severity of the underlying disease, and it negatively affects quality of life and cardio …
with severity of the underlying disease, and it negatively affects quality of life and cardio …
C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation
ACR Epstein, JM Gleadle, LA McNeill, KS Hewitson… - Cell, 2001 - cell.com
HIF is a transcriptional complex that plays a central role in mammalian oxygen homeostasis.
Recent studies have defined posttranslational modification by prolyl hydroxylation as a key …
Recent studies have defined posttranslational modification by prolyl hydroxylation as a key …
Oxygen sensing by HIF hydroxylases
CJ Schofield, PJ Ratcliffe - Nature reviews Molecular cell biology, 2004 - nature.com
The transcription factor HIF (hypoxia-inducible factor) has a central role in oxygen
homeostasis in animals ranging from nematode worms to man. Recent studies have shown …
homeostasis in animals ranging from nematode worms to man. Recent studies have shown …
Inflammation-induced tryptophan breakdown is related with anemia, fatigue, and depression in cancer
L Lanser, P Kink, EM Egger, W Willenbacher… - Frontiers in …, 2020 - frontiersin.org
Many patients with cancer suffer from anemia, depression, and an impaired quality of life
(QoL). These patients often also show decreased plasma tryptophan levels and increased …
(QoL). These patients often also show decreased plasma tryptophan levels and increased …
HIF-1 and mechanisms of hypoxia sensing
GL Semenza - Current opinion in cell biology, 2001 - Elsevier
Hypoxia-inducible factor 1 (HIF-1) is an oxygen-regulated transcriptional activator that plays
essential roles in mammalian development, physiology and disease pathogenesis. The HIF …
essential roles in mammalian development, physiology and disease pathogenesis. The HIF …
The role of nitric oxide in tumour progression
D Fukumura, S Kashiwagi, RK Jain - Nature Reviews Cancer, 2006 - nature.com
Nitric oxide (NO) and nitric oxide synthases are ubiquitous in malignant tumours and are
known to exert both pro-and anti-tumour effects. We summarize our current understanding of …
known to exert both pro-and anti-tumour effects. We summarize our current understanding of …
Cycling hypoxia and free radicals regulate angiogenesis and radiotherapy response
MW Dewhirst, Y Cao, B Moeller - Nature Reviews Cancer, 2008 - nature.com
Hypoxia and free radicals, such as reactive oxygen and nitrogen species, can alter the
function and/or activity of the transcription factor hypoxia-inducible factor 1 (HIF1). Interplay …
function and/or activity of the transcription factor hypoxia-inducible factor 1 (HIF1). Interplay …