ImmunoPET: concept, design, and applications

W Wei, ZT Rosenkrans, J Liu, G Huang, QY Luo… - Chemical …, 2020 - ACS Publications
Immuno-positron emission tomography (immunoPET) is a paradigm-shifting molecular
imaging modality combining the superior targeting specificity of monoclonal antibody (mAb) …

[HTML][HTML] Prospective of 68Ga-radiopharmaceutical development

I Velikyan - Theranostics, 2014 - ncbi.nlm.nih.gov
Abstract Positron Emission Tomography (PET) experienced accelerated development and
has become an established method for medical research and clinical routine diagnostics on …

[HTML][HTML] Pretargeted molecular imaging and radioimmunotherapy

DM Goldenberg, CH Chang, EA Rossi, J William… - Theranostics, 2012 - ncbi.nlm.nih.gov
Pretargeting is a multi-step process that first has an unlabeled bispecific antibody (bsMAb)
localize within a tumor by virtue of its anti-tumor binding site (s) before administering a small …

[HTML][HTML] Pretargeted imaging and radioimmunotherapy of cancer using antibodies and bioorthogonal chemistry

FCJ van de Watering, M Rijpkema, M Robillard… - Frontiers in …, 2014 - frontiersin.org
Selective delivery of radionuclides to tumors may be accomplished using a two-step
approach, in which in the first step the tumor is pretargeted with an unlabeled antibody …

Prospective of 68Ga Radionuclide Contribution to the Development of Imaging Agents for Infection and Inflammation

I Velikyan - Contrast Media & Molecular Imaging, 2018 - Wiley Online Library
During the last decade, the utilization of 68Ga for the development of imaging agents has
increased considerably with the leading position in the oncology. The imaging of infection …

Phase II trial of anticarcinoembryonic antigen pretargeted radioimmunotherapy in progressive metastatic medullary thyroid carcinoma: biomarker response and …

PY Salaun, L Campion, C Bournaud… - Journal of Nuclear …, 2012 - Soc Nuclear Med
The prognosis of medullary thyroid carcinoma (MTC) varies from long-to short-term survival
based on such prognostic factors as serum calcitonin and carcinoembryonic antigen (CEA) …

Promising clinical performance of pretargeted immuno-PET with anti-CEA bispecific antibody and gallium-68-labelled IMP-288 peptide for imaging colorectal cancer …

Y Touchefeu, C Bailly, E Frampas, T Eugène… - European Journal of …, 2021 - Springer
Introduction This pilot study evaluated the imaging performance of pretargeted
immunological positron emission tomography (immuno-PET) using an anti …

Pretargeting: taking an alternate route for localizing radionuclides

RM Sharkey, CH Chang, EA Rossi, WJ McBride… - Tumor Biology, 2012 - Springer
Bispecific antibody pretargeting is a two-step procedure for selectively delivering
radionuclides to tumors. The procedure was developed to solve a number of problems …

The dock-and-lock method combines recombinant engineering with site-specific covalent conjugation to generate multifunctional structures

EA Rossi, DM Goldenberg, CH Chang - Bioconjugate Chemistry, 2012 - ACS Publications
Advances in recombinant protein technology have facilitated the production of increasingly
complex fusion proteins with multivalent, multifunctional designs for use in various in vitro …

[HTML][HTML] Improvement of radioimmunotherapy using pretargeting

E Frampas, C Rousseau, C Bodet-Milin, J Barbet… - Frontiers in …, 2013 - frontiersin.org
During the past two decades, considerable research has been devoted to radionuclide
therapy using radiolabeled monoclonal antibodies and receptor binding agents …