The use of psychoactive drugs is a wide spread behaviour in human societies. The
systematic use of a drug requires the establishment of different drug use-associated …

Drug abuse and dependence are multifaceted disorders with complex genetic
underpinnings. Identifying specific genetic correlates is challenging and may be more …

Heroin addiction is a chronic complex disease with a substantial genetic contribution. This
study was designed to identify genetic variants that are associated with susceptibility to …

Abstract Tryptophan hydroxylase 2 (TPH2) is the rate-limiting enzyme in brain serotonin
synthesis. The TPH2 gene has frequently been investigated in relation to psychiatric …

Addiction to opiates and illicit use of psychostimulants is a chronic, relapsing brain disease
that, if left untreated, can cause major medical, social, and economic problems. This article …

Abstract Serotonin (5HT) modulates the stress response by interacting with the hormonal
hypothalamic–pituitary–adrenal (HPA) axis and neuronal sympathetic nervous system …

Heroin addiction is a chronic complex disease with a substantial genetic contribution. This
study was designed to identify gene variants associated with heroin addiction in African …

The development of an impulse control disorder (ICD) is now recognized as a potential
nonmotor adverse effect of dopamine replacement therapy in Parkinson's disease (PD) …

Objectives We have used genome-wide association studies to identify variants that are
associated with vulnerability to develop heroin addiction. Methods DNA from 325 …

Tryptophan hydroxylase (TPH) catalyzes the rate-limiting step of serotonin synthesis. TPH2
is the brain-specific isoform of this enzyme, and genetic variations in the TPH2 gene have …