The accidental discovery of the anticancer properties of cisplatin in the mid-1960s triggered
the development of alternative platinum-based drugs. However, the platinum-based …

Recent advances on differently-expressed gene products and their functions during the
progression from localized androgen-dependent states into androgen-independent and …

Earlier studies using prostate cancer cells in culture showed that phenethyl isothiocyanate
(PEITC) and curcumin have significant chemopreventive and possibly chemotherapeutic …

Among the nonplatinum antitumor drugs, gold (III)‐dithiocarbamato derivatives have recently
attracted considerable attention due to their strong in vitro and in vivo antiproliferative activity …

Prostate cancer is initially dependent on androgens for growth; hence, recurrent prostate is
treated with androgen ablation which may result in progression to androgen independence …

Cancer cells try to avoid the overproduction of reactive oxygen species by metabolic
rearrangements. These cells also develop specific strategies to increase ROS resistance …

Oncogenic activation of the epidermal growth factor receptor (EGFR) signaling pathway
occurs in a variety of tumor types, albeit in human melanoma, the contribution of EGFR is still …

In the last decade, we have been developing some gold (III) derivatives showing interesting
antitumor properties and reduced systemic and renal toxicity, compared to the clinically …

In the male, androgens promote growth and differentiation of sex reproductive organs
through ligand activation of the androgen receptor (AR). Here, we show that androgens are …

BRCA2 is a multifunctional tumor suppressor protein which plays critical roles in DNA repair,
transcription, and cell proliferation, and the loss of which has been linked to the biology of …