Tumor microenvironment diversity and plasticity in cancer multidrug resistance

Z Li, P Yin - Biochimica et Biophysica Acta (BBA)-Reviews on …, 2023 - Elsevier
Multidrug resistance (MDR) poses a significant obstacle to effective cancer treatment, and
the tumor microenvironment (TME) is crucial for MDR development and reversal. The TME …

Overview of recent advances in nano-based ocular drug delivery

LC Liu, YH Chen, DW Lu - International Journal of Molecular Sciences, 2023 - mdpi.com
Ocular diseases profoundly impact patients' vision and overall quality of life globally.
However, effective ocular drug delivery presents formidable challenges within clinical …

A novel electrospun nanofiber system with PEGylated paclitaxel nanocrystals enhancing the transmucus permeability and in situ retention for an efficient …

H Duan, H Chen, C Qi, F Lv, J Wang, Y Liu, Z Liu… - International Journal of …, 2024 - Elsevier
Overcoming the vaginal barrier to achieve sufficient drug penetration and retention is a huge
obstacle for drug delivery in chemotherapeutics for cervical cancer. In this study, we …

Nanotechnology development in surgical applications: recent trends and developments

F Abaszadeh, MH Ashoub, G Khajouie… - European journal of …, 2023 - Springer
This paper gives a detailed analysis of nanotechnology's rising involvement in numerous
surgical fields. We investigate the use of nanotechnology in orthopedic surgery …

Pharmaceutical Emulsions: A Viable Approach for Ocular Drug Delivery

AC Bisen, S Srivastava, A Mishra… - Journal of Ocular …, 2024 - liebertpub.com
Ocular disorders can lead to serious sight impairment and irreversible blindness. Generally
simple topical and systemic treatments are recommended for treating these vision …

[HTML][HTML] Evaluation of the immune-modulatory, anti-oxidant, proliferative, and anti-apoptotic effects of nano-silymarin on mesenchymal stem cells isolated from multiple …

FL Arab, F Yousefi, MR Jaafari, A Rajabian… - Journal of Functional …, 2024 - Elsevier
Silymarin (SL) has a long history of use for the treatment of a variety of diseases, but several
limitations, such as poor bioavailability and negligible solubility, have restricted its …

Physical and mechanical properties of ocular thin films: a systematic review and meta-analysis

M Farahmandnejad, S Alipour, A Nokhodchi - Drug Discovery Today, 2024 - Elsevier
The ocular thin film presents a potential solution for addressing challenges to ocular drug
delivery. In this review, we summarise the findings of a comprehensive review analysing 336 …

Baicalein glycymicelle ophthalmic solution: Preparation, in vitro antimicrobial activities, and antimicrobial mechanism evaluations

J Zhang, Y Li, S Xie, H Lou, H Chen, G Zhang - International Journal of …, 2024 - Elsevier
The purpose of this study was to develop a novel baicalein (BAI) loaded glycymicelle
ophthalmic solution with small molecule phytochemical glycyrrhizin as nanocarriers and to …

Absorption enhancement strategies in chitosan-based nanosystems and hydrogels intended for ocular delivery: Latest advances for optimization of drug permeation

I Dmour - Carbohydrate Polymers, 2024 - Elsevier
Ophthalmic diseases can be presented as acute diseases like allergies, ocular infections,
etc., or chronic ones that can be manifested as a result of systemic disorders, like diabetes …

Bacteriophages as nanocarriers for targeted drug delivery and enhanced therapeutic effects

SC Emencheta, AL Onugwu, CF Kalu, PN Ezinkwo… - Materials …, 2024 - pubs.rsc.org
The effective delivery of therapeutic agents is as important as the active therapeutic agent
because it may make or mar the outcome. Traditional/conventional drug delivery systems …