Cancer is a complex disease and cancer cells typically harbor multiple genetic and
epigenetic alterations. Large-scale sequencing of patient-derived cancer samples has …

The lung microbiome plays an essential role in maintaining healthy lung function, including
host immune homeostasis. Lung microbial dysbiosis or disruption of the gut-lung axis can …

Acquired resistance to tyrosine kinase inhibitors (TKI), such as osimertinib used to treat
EGFR-mutant lung adenocarcinomas, limits long-term efficacy and is frequently caused by …

Background Brain malignancies encompass gliomas and brain metastases originating from
extracranial tumours including lung cancer. Approximately 50% of patients with lung …

Epigenetic research has the potential to improve our understanding of the pathogenesis of
cancer, specifically non-small-cell lung cancer, and support our efforts to personalize the …

Abstract Treatment with epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors
(TKIs) has brought significant benefits to non-small cell lung cancer (NSCLC) patients with …

The incidence and mortality of lung cancer rank top three of all cancers worldwide.
Accounting for 85% of the total number of lung cancer, non-small cell lung cancer (NSCLC) …

Targeted therapy with tyrosine kinase inhibitors (TKI) provides survival benefits to a majority
of patients with non-small cell lung cancer (NSCLC). However, resistance to TKI almost …

Simple Summary Liquid biopsy is a highly useful tool for the management of NSCLC
patients and could provide valuable information on early detection of resistance to …

Receptor tyrosine kinases (RTKs), a category of transmembrane receptors, have gained
significant clinical attention in oncology due to their central role in cancer pathogenesis …