Protein phase separation and its role in tumorigenesis

S Jiang, JB Fagman, C Chen, S Alberti, B Liu - Elife, 2020 - elifesciences.org
Cancer is a disease characterized by uncontrolled cell proliferation, but the precise
pathological mechanisms underlying tumorigenesis often remain to be elucidated. In recent …

Y-box-binding protein 1 (YB-1) and its functions

IA Eliseeva, ER Kim, SG Guryanov… - Biochemistry …, 2011 - Springer
This review describes the structure and functions of Y-box binding protein 1 (YB-1) and its
homologs. Interactions of YB-1 with DNA, mRNAs, and proteins are considered. Data on the …

[PDF][PDF] Translational activation of HIF1α by YB-1 promotes sarcoma metastasis

AM El-Naggar, CJ Veinotte, H Cheng, TGP Grunewald… - Cancer cell, 2015 - cell.com
Metastatic dissemination is the leading cause of death in cancer patients, which is
particularly evident for high-risk sarcomas such as Ewing sarcoma, osteosarcoma, and …

YB-1 regulates stress granule formation and tumor progression by translationally activating G3BP1

SP Somasekharan, A El-Naggar, G Leprivier… - Journal of Cell …, 2015 - rupress.org
Under cell stress, global protein synthesis is inhibited to preserve energy. One mechanism is
to sequester and silence mRNAs in ribonucleoprotein complexes known as stress granules …

Hypoxia-induced LncRNA-BX111 promotes metastasis and progression of pancreatic cancer through regulating ZEB1 transcription

S Deng, H Chen, Z Ye, S Deng, S Zhu, Z Zeng, C He… - Oncogene, 2018 - nature.com
The contribution of long noncoding RNAs (lncRNAs) to pancreatic cancer progression and
the regulatory mechanisms of their expression are attractive areas. In the present study, the …

Altered expression of genes involved in inflammation and apoptosis in frontal cortex in major depression

RC Shelton, J Claiborne… - Molecular …, 2011 - nature.com
The etiology of major depression (MDD), a common and complex disorder, remains
obscure. Gene expression profiling was conducted on post-mortem brain tissue samples …

[PDF][PDF] Translational activation of snail1 and other developmentally regulated transcription factors by YB-1 promotes an epithelial-mesenchymal transition

V Evdokimova, C Tognon, T Ng, P Ruzanov, N Melnyk… - Cancer cell, 2009 - cell.com
Increased expression of the transcription/translation regulatory protein Y-box binding protein-
1 (YB-1) is associated with cancer aggressiveness, particularly in breast carcinoma. Here …

YB-1 regulates tiRNA-induced Stress Granule formation but not translational repression

SM Lyons, C Achorn, NL Kedersha… - Nucleic acids …, 2016 - academic.oup.com
Abstract Stress-induced angiogenin (ANG)-mediated tRNA cleavage promotes a cascade of
cellular events that starts with production of tRNA-derived stress-induced RNAs (tiRNAs) …

Splicing factor YBX1 regulates bone marrow stromal cell fate during aging

Y Xiao, GP Cai, X Feng, YJ Li, WH Guo, Q Guo… - The EMBO …, 2023 - embopress.org
Senescence and altered differentiation potential of bone marrow stromal cells (BMSCs) lead
to age‐related bone loss. As an important posttranscriptional regulatory pathway, alternative …

Regulation of RNA splicing by the methylation-dependent transcriptional repressor methyl-CpG binding protein 2

JI Young, EP Hong, JC Castle… - Proceedings of the …, 2005 - National Acad Sciences
Rett syndrome (RTT) is a postnatal neurodevelopmental disorder characterized by the loss
of acquired motor and language skills, autistic features, and unusual stereotyped …