Introduction Basal-like breast cancers (BLBCs) are very aggressive, and present serious
clinical challenges as there are currently no targeted therapies available. We determined the …

Gene expression can be regulated by nuclear factors at the transcriptional level. Many such
factors regulate MDR1 gene expression, but what are the sequence elements and …

The tumor suppressor p53 is activated upon cellular stresses such as DNA damage,
oncogene activation, hypoxia, which transactivates sets of genes that induce DNA repair …

The recently characterized enzyme NEIL2 (Nei-like-2), one of the four oxidized base-specific
DNA glycosylases (OGG1, NTH1, NEIL1, and NEIL2) in mammalian cells, has poor base …

Epithelial-to-mesenchymal transition (EMT) plays an important role in prostate cancer (PCa)
metastasis. The transcription/translation regulatory Y-box binding protein-1 (YB-1) is known …

MSY2, a germ-cell-specific member of the Y-box family of DNA-/RNA-binding proteins, is
proposed to function as a coactivator of transcription in the nucleus and to stabilize and store …

YB-1 protein levels are elevated in most human breast cancers, and high YB-1 levels have
been correlated with drug resistance and poor clinical outcome. YB-1 is a stress-responsive …

Dengue virus, a member of the family Flaviviridae, poses a serious public health threat
worldwide. Dengue virus is a positive-sense RNA virus that harbors a genome of∼ 10.7 kb …

The Notch signaling cascade is an evolutionarily ancient system that allows cells to interact
with their microenvironmental neighbors through direct cell-cell interactions, thereby …

Hepatocellular carcinoma (HCC) is the most common liver malignancy and a leading cause
of cancer-related mortality worldwide. Accurate detection and differential diagnosis of early …