Challenges for identifying functionally important genetic variation: the promise of combining complementary research strategies

A Vasemägi, CR Primmer - Molecular Ecology, 2005 - Wiley Online Library
Strategies for the identification of functional genetic variation underlying phenotypic traits of
ecological and evolutionary importance have received considerable attention in the …

Corn and humans: recombination and linkage disequilibrium in two genomes of similar size

A Rafalski, M Morgante - TRENDS in Genetics, 2004 - cell.com
Two species with genomes of almost identical size, maize and human, have different
evolutionary histories, and as a result their genomes differ greatly in their content of …

The genetics of variation in gene expression

VG Cheung, RS Spielman - Nature genetics, 2002 - nature.com
The genetic basis of variation in gene expression lends itself to investigation by microarrays.
For genetic analysis, we view the expression level of a gene as a quantitative …

Association analysis using SSR markers to find QTL for seed protein content in soybean

TH Jun, K Van, MY Kim, SH Lee, DR Walker - Euphytica, 2008 - Springer
Association analysis studies can be used to test for associations between molecular markers
and quantitative trait loci (QTL). In this study, a genome-wide scan was performed using 150 …

Parallel genotyping of over 10,000 SNPs using a one-primer assay on a high-density oligonucleotide array

H Matsuzaki, H Loi, S Dong, YY Tsai, J Fang… - Genome …, 2004 - genome.cshlp.org
The analysis of single nucleotide polymorphisms (SNPs) is increasingly utilizedto
investigate the genetic causes of complex human diseases. Here we present a high …

A comprehensive review of the genetics of juvenile idiopathic arthritis

S Prahalad, DN Glass - Pediatric Rheumatology, 2008 - Springer
Juvenile idiopathic arthritis (JIA) is the most common chronic arthropathy of childhood which
is believed to be influenced by both genetic and environmental factors. The progress in …

Shaking the tree: mapping complex disease genes with linkage disequilibrium

LJ Palmer, LR Cardon - The Lancet, 2005 - thelancet.com
Much effort and expense are being spent internationally to detect genetic polymorphisms
contributing to susceptibility to complex human disease. Concomitantly, the technology for …

Population structure and breeding patterns of 145 US rice cultivars based on SSR marker analysis

H Lu, MA Redus, JR Coburn, JN Rutger… - Crop …, 2005 - Wiley Online Library
This study was undertaken to investigate the population structure of US rice (Oryza sativa
L.). A total of 115 US rice cultivars and 30 ancestral accessions introduced from Asia were …

SNP association studies in Alzheimer's disease highlight problems for complex disease analysis

T Emahazion, L Feuk, M Jobs, SL Sawyer… - TRENDS in …, 2001 - cell.com
Genetic linkage and association analyses are two distinct approaches to understanding the
genetic etiology of complex disease. Association analysis has become particularly popular …

The Ph1 locus is needed to ensure specific somatic and meiotic centromere association

E Martinez-Perez, P Shaw, G Moore - Nature, 2001 - nature.com
The correct pairing and segregation of chromosomes during meiosis is essential for genetic
stability and subsequent fertility. This is more difficult to achieve in polyploid species, such …