Immunological effects of conventional chemotherapy and targeted anticancer agents
The tremendous clinical success of checkpoint blockers illustrates the potential of
reestablishing latent immunosurveillance for cancer therapy. Although largely neglected in …
reestablishing latent immunosurveillance for cancer therapy. Although largely neglected in …
[HTML][HTML] Targeting the tumor microenvironment: removing obstruction to anticancer immune responses and immunotherapy
JM Pitt, A Marabelle, A Eggermont, JC Soria… - Annals of …, 2016 - Elsevier
The tumor microenvironment (TME) is an integral part of cancer. Recognition of the essential
nature of the TME in cancer evolution has led to a shift from a tumor cell-centered view of …
nature of the TME in cancer evolution has led to a shift from a tumor cell-centered view of …
The tumour microenvironment after radiotherapy: mechanisms of resistance and recurrence
Radiotherapy plays a central part in curing cancer. For decades, most research on
improving treatment outcomes has focused on modulating radiation-induced biological …
improving treatment outcomes has focused on modulating radiation-induced biological …
Cell death and immunity in cancer: from danger signals to mimicry of pathogen defense responses
AD Garg, P Agostinis - Immunological reviews, 2017 - Wiley Online Library
The immunogenicity of cancer cells is an emerging determinant of anti‐cancer
immunotherapy. Beyond developing immunostimulatory regimens like dendritic cell‐based …
immunotherapy. Beyond developing immunostimulatory regimens like dendritic cell‐based …
Metal drugs and the anticancer immune response
B Englinger, C Pirker, P Heffeter, A Terenzi… - Chemical …, 2018 - ACS Publications
The immune system deploys a multitude of innate and adaptive mechanisms not only to
ward off pathogens but also to prevent malignant transformation (“immune surveillance”) …
ward off pathogens but also to prevent malignant transformation (“immune surveillance”) …
From immunogenic cell death to immunogenic modulation: select chemotherapy regimens induce a spectrum of immune-enhancing activities in the tumor …
Cancer treatment has rapidly entered the age of immunotherapy, and it is becoming clear
that the effective therapy of established tumors necessitates rational multi-combination …
that the effective therapy of established tumors necessitates rational multi-combination …
Consensus guidelines for the detection of immunogenic cell death
O Kepp, L Senovilla, I Vitale, E Vacchelli… - …, 2014 - Taylor & Francis
Apoptotic cells have long been considered as intrinsically tolerogenic or unable to elicit
immune responses specific for dead cell-associated antigens. However, multiple stimuli can …
immune responses specific for dead cell-associated antigens. However, multiple stimuli can …
Trial watch: chemotherapy-induced immunogenic cell death in immuno-oncology
The term 'immunogenic cell death'(ICD) denotes an immunologically unique type of
regulated cell death that enables, rather than suppresses, T cell-driven immune responses …
regulated cell death that enables, rather than suppresses, T cell-driven immune responses …
Immunogenic cell death and DAMPs in cancer therapy
Although it was thought that apoptotic cells, when rapidly phagocytosed, underwent a silent
death that did not trigger an immune response, in recent years a new concept of …
death that did not trigger an immune response, in recent years a new concept of …
Immunogenic cell death in cancer therapy
Depending on the initiating stimulus, cancer cell death can be immunogenic or
nonimmunogenic. Immunogenic cell death (ICD) involves changes in the composition of the …
nonimmunogenic. Immunogenic cell death (ICD) involves changes in the composition of the …