Over the past decades, immunotherapy has demonstrated a prominent clinical efficacy in a
wide variety of human tumors. For many years, apoptosis has been considered a non …

Platinum-based drugs, and in particular cis-diamminedichloroplatinum (II)(best known as
cisplatin), are employed for the treatment of a wide array of solid malignancies, including …

It has recently become clear that the tumour microenvironment, and in particular the immune
system, has a crucial role in modulating tumour progression and response to therapy …

Dendritic cells (DCs) are the sentinel antigen-presenting cells of the immune system; such
that their productive interface with the dying cancer cells is crucial for proper communication …

Cancer progression is characterized by rapidly proliferating cancer cells that are in need of
increased protein synthesis. Therefore, enhanced endoplasmic reticulum (ER) activity is …

The treatment of postoperative infection caused by multidrug‐resistant bacteria, such as
methicillin‐resistant Staphylococcus aureus (MRSA), has become an intractable clinical …

The phosphorylation of eIF2α is essential for the endoplasmic reticulum (ER) stress
response, the formation of stress granules, as well as macroautophagy. Several successful …

The outcome of chemotherapy can be influenced by the host immune system at multiple
levels. Chemotherapy can kill cancer cells by causing them to elicit an immune response or …

The term “immunogenic cell death”(ICD) is commonly employed to indicate a peculiar
instance of regulated cell death (RCD) that engages the adaptive arm of the immune system …

Cell death has an important role in many human diseases, and strategies aimed at
modulating the associated pathways have been successfully applied to treat various …