Immunogenic cell death (ICD) offers a method of stimulating the immune system to attack
and remove cancer cells. We report a copper (II) complex containing a Schiff base ligand …

Certain cytotoxic chemotherapeutic drugs are immunogenic, stimulating tumor immunity
through mechanisms that are not completely understood. Here we show how the DNA …

Endoplasmic reticulum (ER) chaperones (eg, calreticulin, heat shock proteins, and
isomerases) perform a multitude of functions within the ER. However, many of these …

Background Chemotherapeutics can stimulate immune antitumor response by inducing
immunogenic cell death (ICD), which is activated by Damage-Associated Molecular Patterns …

Immunotherapy is considered to be one of the most promising methods to overcome cancer.
Immunogenic cell death (ICD), as a special form of cell death that can trigger an antitumor …

Purpose: Cisplatin is increasingly used in chemoimmunotherapy and may enhance the T
cell–dependent radiation-induced abscopal effect, but how it promotes antitumor immunity is …

Cancer is evading the host's defense mechanisms leading to avoidance of immune
destruction. During tumor progression, immune-evading cancer cells arise due to selective …

Conventional chemotherapeutics, but also innovative precision anticancer compounds, are
commonly perceived to target primarily the cancer cell compartment. However, recently it …

Purpose: The purpose of this study was to assess the effect of neoadjuvant chemotherapy
(NACT) on immune activation in stage IIIC/IV tubo-ovarian high-grade serous carcinoma …

Blockade of immune-checkpoints has emerged as one of the most promising approaches to
improve the durability of anti-tumor responses in cancer patients. However, the fraction of …