Vascular cognitive impairment and dementia (VCID) is commonly caused by vascular
injuries in cerebral large and small vessels and is a key driver of age-related cognitive …

As part of the neurovascular unit, the blood-brain barrier (BBB) is a unique, dynamic
regulatory boundary that limits and regulates the exchange of molecules, ions, and cells …

Blood vessels are critical to deliver oxygen and nutrients to all of the tissues and organs
throughout the body. The blood vessels that vascularize the central nervous system (CNS) …

At any point 1–5 days following ascent to altitudes≥ 2500 m, individuals are at risk of
developing one of three forms of acute altitude illness: acute mountain sickness, a syndrome …

Cerebral vasculature and neuronal networks will be largely destroyed due to the oxidative
damage by overproduced reactive oxygen species (ROS) during a stroke, accompanied by …

The critical role of the vasculature and its repair in neurological disease states is beginning
to emerge particularly for stroke, dementia, epilepsy, Parkinson's disease, tumors and …

Abstract CD133 (prominin-1), a pentaspan membrane glycoprotein, is one of the most well-
characterized biomarkers used for the isolation of cancer stem cells (CSCs). The presence …

As the primary protective barrier for neurons in the brain, the blood–brain barrier (BBB)
exists between the blood microcirculation system and the brain parenchyma. The normal …

The hypoxic response is an ancient stress response triggered by low ambient oxygen
(O2)(ref.) and controlled by hypoxia-inducible transcription factor-1 (HIF-1), whose α subunit …

Microglia, the resident immune cells of the brain and retina, are constantly engaged in the
surveillance of their surrounding neural tissue. During embryonic development they infiltrate …