A guide to complement biology, pathology and therapeutic opportunity

DC Mastellos, G Hajishengallis… - Nature Reviews …, 2024 - nature.com
Complement has long been considered a key innate immune effector system that mediates
host defence and tissue homeostasis. Yet, growing evidence has illuminated a broader …

Progress in the Prevalence, Classification and Drug Resistance Mechanisms of Methicillin-Resistant Staphylococcus aureus

Z Hou, L Liu, J Wei, B Xu - Infection and Drug Resistance, 2023 - Taylor & Francis
Staphylococcus aureus is a common human pathogen with a variety of virulence factors,
which can cause multiple infectious diseases. In recent decades, due to the constant …

Multimodal nanoimmunotherapy engages neutrophils to eliminate Staphylococcus aureus infections

J Zhu, R Xie, R Gao, Y Zhao, N Yodsanit, M Zhu… - Nature …, 2024 - nature.com
The increasing prevalence of antimicrobial resistance in Staphylococcus aureus
necessitates alternative therapeutic approaches. Neutrophils play a crucial role in the fight …

Ultrasound‐Stimulated “Exocytosis” by Cell‐Like Microbubbles Enhances Antibacterial Species Penetration and Immune Activation Against Implant Infection

W Xiu, X Li, Q Li, M Ding, Y Zhang, L Wan… - Advanced …, 2024 - Wiley Online Library
Host immune systems serving as crucial defense lines are vital resisting mechanisms
against biofilm‐associated implant infections. Nevertheless, biofilms hinder the penetration …

Genetic diversity, antibiotic resistance, and virulence characteristics of Staphylococcus aureus from raw milk over 10 years in Shanghai

J Huang, W Zhang, B Sun, Q Jiang, Y Cao… - International Journal of …, 2023 - Elsevier
Staphylococcus aureus (S. aureus) is a major cause of foodborne infections and its
persistence in raw milk is a multifaceted phenomenon that poses a considerable public …

Staphylococcus aureus colonisation and strategies for decolonisation

P Piewngam, M Otto - The Lancet Microbe, 2024 - thelancet.com
Staphylococcus aureus is a leading cause of death by infectious diseases worldwide.
Treatment of S aureus infections is difficult due to widespread antibiotic resistance …

Differential survival of Staphylococcal species in macrophages

J Bayer, J Becker, X Liu, L Gritsch… - Molecular …, 2024 - Wiley Online Library
Staphylococcus aureus is considered an extracellular pathogen, yet the bacterium is able to
survive within and escape from host cells. An agr/sae mutant of strain USA300 is unable to …

Electrospun nanofibrous mesh based on PVA, chitosan, and usnic acid for applications in wound healing

AE Stoica, D Albuleț, AC Bîrcă, F Iordache… - International Journal of …, 2023 - mdpi.com
Injuries and diseases of the skin require accurate treatment using nontoxic and noninvasive
biomaterials, which aim to mimic the natural structures of the body. There is a strong need to …

Biofilms in Periprosthetic Orthopedic Infections Seen through the Eyes of Neutrophils: How Can We Help Neutrophils?

CR Arciola, S Ravaioli, R Mirzaei, P Dolzani… - International Journal of …, 2023 - mdpi.com
Despite advancements in our knowledge of neutrophil responses to planktonic bacteria
during acute inflammation, much remains to be elucidated on how neutrophils deal with …

Bacterial Outer Membrane‐Based Biomimetic Immune Adaptors: Mild Immunomodulatory and Bacterial Targeted Delivery Strategy Against Implant‐Related Infections

C Ding, R He, T Cheng, J Wang, X Liu… - Advanced Functional …, 2023 - Wiley Online Library
Implant‐related infections (IRIs) are difficult to manage and are a major cause of surgical
failure. The formation of biofilms with a solid barrier on the surface of implants and …