Genistein: an integrative overview of its mode of action, pharmacological properties, and health benefits

J Sharifi-Rad, C Quispe, M Imran, A Rauf… - Oxidative medicine …, 2021 - Wiley Online Library
Genistein is an isoflavone first isolated from the brooming plant Dyer's Genista tinctoria L.
and is widely distributed in the Fabaceae family. As an isoflavone, mammalian genistein …

Dietary phytochemicals in colorectal cancer prevention and treatment: A focus on the molecular mechanisms involved

S Afrin, F Giampieri, M Gasparrini… - Biotechnology …, 2020 - Elsevier
Worldwide, colorectal cancer (CRC) remains a major cancer type and leading cause of
death. Unfortunately, current medical treatments are not sufficient due to lack of effective …

Adverse effects of cancer chemotherapy: Anything new to improve tolerance and reduce sequelae?

K Nurgali, RT Jagoe, R Abalo - Frontiers in pharmacology, 2018 - frontiersin.org
The side-effects and long-term sequelae of anti-cancer chemotherapy remain a major
source of concern for both patients and clinicians despite the improved efficacy and …

New insights toward colorectal cancer chemotherapy using natural bioactive compounds

S Redondo-Blanco, J Fernández… - Frontiers in …, 2017 - frontiersin.org
Combination therapy consists in the simultaneous administration of a conventional
chemotherapy drug (or sometimes, a radiotherapy protocol) together with one or more …

The PI3K/Akt/mTOR axis in colorectal cancer: oncogenic alterations, non‐coding RNAs, therapeutic opportunities, and the emerging role of nanoparticles

MJ Sanaei… - Journal of Cellular …, 2022 - Wiley Online Library
Colorectal cancer (CRC) is one of the deadliest human malignancies worldwide. Several
molecular pathways have been demonstrated to be involved in the initiation and …

Isoflavones, their glycosides and glycoconjugates. Synthesis and biological activity

W Szeja, G Grynkiewicz, A Rusin - Current Organic Chemistry, 2017 - ingentaconnect.com
Glycosylation of small biologically active molecules, either of natural or synthetic origin, has
a profound impact on their solubility, stability, and bioactivity, making glycoconjugates …

[HTML][HTML] Genistein inhibits human colorectal cancer growth and suppresses miR-95, Akt and SGK1

J Qin, JX Chen, Z Zhu, JA Teng - Cellular physiology and biochemistry, 2015 - karger.com
Background: Genistein, a major isoflavonoid isolated from dietary soybean, has been shown
to suppress the growth of several cancers through modulation of various pathways …

[HTML][HTML] The synergism of natural compounds and conventional therapeutics against colorectal cancer progression and metastasis

Z Liang, H Xie, W Shen, L Shao, L Zeng… - Frontiers in Bioscience …, 2022 - imrpress.com
Cancer progression and metastases are the leading causes of poor outcomes in patients
with colon cancer. Colon cancer metastasis is a multigene, multistep, multistage complex …

Dalbergia sissoo phytochemicals as EGFR inhibitors: an in vitro and in silico approach

HN Naik, D Kanjariya, S Parveen, A Meena… - Journal of …, 2023 - Taylor & Francis
The safest and most effective sources of medications are natural and traditional medicines
derived from plants and herbs. In Western India, various parts of the Dalbergia sissoo plant …

Apigenin inhibits growth of breast cancer cells: the role of ERα and HER2/neu

AM Scherbakov, OE Andreeva - Acta Naturae (англоязычная …, 2015 - cyberleninka.ru
Phytoestrogens are a group of plant-derived compounds with an estrogen-like activity. In
mammalians, phytoestrogens bind to the estrogen receptor (ER) and participate in the …