[HTML][HTML] Sensitive detection of chromosomal segments of distinct ancestry in admixed populations
AL Price, A Tandon, N Patterson, KC Barnes… - PLoS …, 2009 - journals.plos.org
Identifying the ancestry of chromosomal segments of distinct ancestry has a wide range of
applications from disease mapping to learning about history. Most methods require the use …
applications from disease mapping to learning about history. Most methods require the use …
Multiple sclerosis genetics
S Sawcer, RJM Franklin, M Ban - The Lancet Neurology, 2014 - thelancet.com
Genome-wide association studies have revolutionised the genetic analysis of multiple
sclerosis. Through international collaborative efforts involving tens of thousands of cases …
sclerosis. Through international collaborative efforts involving tens of thousands of cases …
MYH9 is a major-effect risk gene for focal segmental glomerulosclerosis
The increased burden of chronic kidney and end-stage kidney diseases (ESKD) in
populations of African ancestry has been largely unexplained. To identify genetic variants …
populations of African ancestry has been largely unexplained. To identify genetic variants …
Genome-wide patterns of population structure and admixture in West Africans and African Americans
Quantifying patterns of population structure in Africans and African Americans illuminates
the history of human populations and is critical for undertaking medical genomic studies on …
the history of human populations and is critical for undertaking medical genomic studies on …
Estimation of individual admixture: analytical and study design considerations
The genome of an admixed individual represents a mixture of alleles from different
ancestries. In the United States, the two largest minority groups, African‐Americans and …
ancestries. In the United States, the two largest minority groups, African‐Americans and …
MYH9 is associated with nondiabetic end-stage renal disease in African Americans
WHL Kao, MJ Klag, LA Meoni, D Reich… - Nature …, 2008 - nature.com
As end-stage renal disease (ESRD) has a four times higher incidence in African Americans
compared to European Americans, we hypothesized that susceptibility alleles for ESRD …
compared to European Americans, we hypothesized that susceptibility alleles for ESRD …
Ancestry informative marker sets for determining continental origin and admixture proportions in common populations in America
To provide a resource for assessing continental ancestry in a wide variety of genetic studies,
we identified, validated, and characterized a set of 128 ancestry informative markers (AIMs) …
we identified, validated, and characterized a set of 128 ancestry informative markers (AIMs) …
[PDF][PDF] Long-range LD can confound genome scans in admixed populations
AL Price, ME Weale, N Patterson, SR Myers… - The American Journal of …, 2008 - cell.com
To the Editor: In the September 2007 issue of The Journal, Tang et al. analyzed data from
192 Puerto Ricans genotyped at 112,584 autosomal markers and identified three regions …
192 Puerto Ricans genotyped at 112,584 autosomal markers and identified three regions …
Implications of biogeography of human populations for'race'and medicine
SA Tishkoff, KK Kidd - Nature genetics, 2004 - nature.com
In this review, we focus on the biogeographical distribution of genetic variation and address
whether or not populations cluster according to the popular concept of'race'. We show that …
whether or not populations cluster according to the popular concept of'race'. We show that …
[HTML][HTML] Geographic patterns of genome admixture in Latin American Mestizos
The large and diverse population of Latin America is potentially a powerful resource for
elucidating the genetic basis of complex traits through admixture mapping. However, no …
elucidating the genetic basis of complex traits through admixture mapping. However, no …