[HTML][HTML] Sensitive detection of chromosomal segments of distinct ancestry in admixed populations

AL Price, A Tandon, N Patterson, KC Barnes… - PLoS …, 2009 - journals.plos.org
Identifying the ancestry of chromosomal segments of distinct ancestry has a wide range of
applications from disease mapping to learning about history. Most methods require the use …

Multiple sclerosis genetics

S Sawcer, RJM Franklin, M Ban - The Lancet Neurology, 2014 - thelancet.com
Genome-wide association studies have revolutionised the genetic analysis of multiple
sclerosis. Through international collaborative efforts involving tens of thousands of cases …

MYH9 is a major-effect risk gene for focal segmental glomerulosclerosis

JB Kopp, MW Smith, GW Nelson, RC Johnson… - Nature …, 2008 - nature.com
The increased burden of chronic kidney and end-stage kidney diseases (ESKD) in
populations of African ancestry has been largely unexplained. To identify genetic variants …

Genome-wide patterns of population structure and admixture in West Africans and African Americans

K Bryc, A Auton, MR Nelson… - Proceedings of the …, 2010 - National Acad Sciences
Quantifying patterns of population structure in Africans and African Americans illuminates
the history of human populations and is critical for undertaking medical genomic studies on …

Estimation of individual admixture: analytical and study design considerations

H Tang, J Peng, P Wang… - Genetic Epidemiology: The …, 2005 - Wiley Online Library
The genome of an admixed individual represents a mixture of alleles from different
ancestries. In the United States, the two largest minority groups, African‐Americans and …

MYH9 is associated with nondiabetic end-stage renal disease in African Americans

WHL Kao, MJ Klag, LA Meoni, D Reich… - Nature …, 2008 - nature.com
As end-stage renal disease (ESRD) has a four times higher incidence in African Americans
compared to European Americans, we hypothesized that susceptibility alleles for ESRD …

Ancestry informative marker sets for determining continental origin and admixture proportions in common populations in America

R Kosoy, R Nassir, C Tian, PA White, LM Butler… - Human …, 2009 - Wiley Online Library
To provide a resource for assessing continental ancestry in a wide variety of genetic studies,
we identified, validated, and characterized a set of 128 ancestry informative markers (AIMs) …

[PDF][PDF] Long-range LD can confound genome scans in admixed populations

AL Price, ME Weale, N Patterson, SR Myers… - The American Journal of …, 2008 - cell.com
To the Editor: In the September 2007 issue of The Journal, Tang et al. analyzed data from
192 Puerto Ricans genotyped at 112,584 autosomal markers and identified three regions …

Implications of biogeography of human populations for'race'and medicine

SA Tishkoff, KK Kidd - Nature genetics, 2004 - nature.com
In this review, we focus on the biogeographical distribution of genetic variation and address
whether or not populations cluster according to the popular concept of'race'. We show that …

[HTML][HTML] Geographic patterns of genome admixture in Latin American Mestizos

S Wang, N Ray, W Rojas, MV Parra, G Bedoya… - PLoS …, 2008 - journals.plos.org
The large and diverse population of Latin America is potentially a powerful resource for
elucidating the genetic basis of complex traits through admixture mapping. However, no …