Phenotypic associations of genetic susceptibility loci in systemic lupus erythematosus

E Sanchez, A Nadig, BC Richardson… - Annals of the …, 2011 - ard.bmj.com
Objective Systemic lupus erythematosus is a clinically heterogeneous autoimmune disease.
A number of genetic loci that increase lupus susceptibility have been established. This study …

Genetic admixture and asthma‐related phenotypes in Mexican American and Puerto Rican asthmatics

K Salari, S Choudhry, H Tang, M Naqvi… - … Official Publication of …, 2005 - Wiley Online Library
Genetic association studies in admixed populations may be biased if individual ancestry
varies within the population and the phenotype of interest is associated with ancestry …

[PDF][PDF] Admixture mapping of an allele affecting interleukin 6 soluble receptor and interleukin 6 levels

D Reich, N Patterson, V Ramesh, PL De Jager… - The American Journal of …, 2007 - cell.com
Circulating levels of inflammatory markers can predict cardiovascular disease risk. To
identify genes influencing the levels of these markers, we genotyped 1,343 single …

[PDF][PDF] Prospects for admixture mapping of complex traits

PM McKeigue - The American Journal of Human Genetics, 2005 - cell.com
Admixture mapping extends to human populations the principles that underlie linkage
analysis of an experimental cross. For detecting genes that contribute to ethnic variation in …

[HTML][HTML] Ancestry analysis in the 11-M Madrid bomb attack investigation

C Phillips, L Prieto, M Fondevila, A Salas… - PloS one, 2009 - journals.plos.org
The 11-M Madrid commuter train bombings of 2004 constituted the second biggest terrorist
attack to occur in Europe after Lockerbie, while the subsequent investigation became the …

The complex genetics of multiple sclerosis: pitfalls and prospects

S Sawcer - Brain, 2008 - academic.oup.com
The genetics of complex disease is entering a new and exciting era. The exponentially
growing knowledge and technological capabilities emerging from the human genome …

[HTML][HTML] Enhanced statistical tests for GWAS in admixed populations: assessment using African Americans from CARe and a Breast Cancer Consortium

B Pasaniuc, N Zaitlen, G Lettre, GK Chen… - PLoS …, 2011 - journals.plos.org
While genome-wide association studies (GWAS) have primarily examined populations of
European ancestry, more recent studies often involve additional populations, including …

Examination of ancestry and ethnic affiliation using highly informative diallelic DNA markers: application to diverse and admixed populations and implications for …

N Yang, H Li, LA Criswell, PK Gregersen… - Human genetics, 2005 - Springer
We and others have identified several hundred ancestry informative markers (AIMs) with
large allele frequency differences between different major ancestral groups. For this study, a …

The ethnic/racial variations of intracerebral hemorrhage (ERICH) study protocol

D Woo, J Rosand, C Kidwell, JL McCauley, J Osborne… - Stroke, 2013 - Am Heart Assoc
Background and Purpose—Epidemiological studies of intracerebral hemorrhage (ICH) have
consistently demonstrated variation in incidence, location, age at presentation, and …

[HTML][HTML] Admixture mapping in lupus identifies multiple functional variants within IFIH1 associated with apoptosis, inflammation, and autoantibody production

JE Molineros, AK Maiti, C Sun, LL Looger, S Han… - PLoS …, 2013 - journals.plos.org
Systemic lupus erythematosus (SLE) is an inflammatory autoimmune disease with a strong
genetic component. African-Americans (AA) are at increased risk of SLE, but the genetic …