Flavonoids as promising neuroprotectants and their therapeutic potential against Alzheimer's disease

T Minocha, H Birla, AA Obaid, V Rai… - Oxidative Medicine …, 2022 - Wiley Online Library
Alzheimer's disease (AD) is one of the serious and progressive neurodegenerative
disorders in the elderly worldwide. Various genetic, environmental, and lifestyle factors are …

The pivotal role of JAK/STAT and IRS/PI3K signaling pathways in neurodegenerative diseases: Mechanistic approaches to polyphenols and alkaloids

L Kooshki, SN Zarneshan, S Fakhri, SZ Moradi… - Phytomedicine, 2023 - Elsevier
Abstract Background Neurodegenerative diseases (NDDs) are characterized by progressive
neuronal dysfunctionality which results in disability and human life-threatening events. In …

Neuroprotective effect of artichoke-based nanoformulation in sporadic Alzheimer's disease mouse model: focus on antioxidant, anti-inflammatory, and amyloidogenic …

HAS El-Nashar, H Abbas, M Zewail, MH Noureldin… - Pharmaceuticals, 2022 - mdpi.com
The vast socio-economic impact of Alzheimer's disease (AD) has prompted the search for
new neuroprotective agents with good tolerability and safety profile. With its outstanding role …

Flavonoids from Seabuckthorn (Hippophae rhamnoides L.) restore CUMS-induced depressive disorder and regulate the gut microbiota in mice

CX Xia, AX Gao, Y Zhu, TTX Dong, KWK Tsim - Food & Function, 2023 - pubs.rsc.org
Seabuckthorn (Hippophae rhamnoides L.), which is enriched with flavonoids, including
isorhamnetin, quercetin and kaempferol, is a representative example of “medicine food …

Potential innovation against Alzheimer's disorder: A tricomponent combination of natural antioxidants (vitamin E, quercetin, and basil oil) and the development of its …

C Karthika, AP Appu, R Akter, MH Rahman… - … Science and Pollution …, 2022 - Springer
Alzheimer's disorder (AD) is very difficult to manage and treat. The complexity of the brain,
the blood–brain barrier influencing a multitude of parameters/biomarkers, as well as …

Exploring the therapeutic potential of phytochemicals in Alzheimer's disease: Focus on polyphenols and monoterpenes

I Piccialli, V Tedeschi, L Caputo, S D'Errico… - Frontiers in …, 2022 - frontiersin.org
Alzheimer's disease (AD) is a chronic, complex neurodegenerative disorder mainly
characterized by the irreversible loss of memory and cognitive functions. Different …

Luteolin: A promising natural agent in management of pain in chronic conditions

F Ntalouka, A Tsirivakou - Frontiers in Pain Research, 2023 - frontiersin.org
Pain due to chronic conditions is a frequent and insufficiently addressed problem. Current
drug options for pain management (either in cases of chronic inflammatory conditions or …

Paradigm shift in phytochemicals research: Evolution from antioxidant capacity to anti-inflammatory effect and to roles in gut health and metabolic syndrome

L Xiao, Y Sun, R Tsao - Journal of Agricultural and Food …, 2022 - ACS Publications
Food bioactive components, particularly phytochemicals with antioxidant capacity, have
been extensively studied over the past two decades. However, as new analytical and …

Modulation of the gut microbiota in memory impairment and alzheimer's disease via the inhibition of the parasympathetic nervous system

S Park, X Wu - International journal of molecular sciences, 2022 - mdpi.com
The gut microbiota has been demonstrated to play a critical role in maintaining cognitive
function via the gut-brain axis, which may be related to the parasympathetic nervous system …

Comprehensive review of nutraceuticals against cognitive decline associated with Alzheimer's disease

EE Reza-Zaldívar, DA Jacobo-Velázquez - ACS omega, 2023 - ACS Publications
Nowadays, nutraceuticals are being incorporated into functional foods or used as
supplements with nonpharmacological approaches in the prevention and management of …