Intracellular signalling pathways have provided excellent resource for drug development
particularly in the development of cancer therapeutics. A wide variety of malignancies …

Introduction 3. NF-kappaB activation pathways 3.1. Protein components in the NF-kappaB
family 3.2. The pathways leading to NF-kappaB activation 4. NF-kappaB's cellular functions …

Background The aim of this study was to evaluate the influence of statins on the growth of
small abdominal aortic aneurysms (AAAs). Methods We retrospectively examined AAA …

Abdominal aortic aneurysm (AAA) is a vascular pathology with a high rate of morbidity and
mortality and a prevalence that, in men over 65 years, can reach around 8%. In this disease …

Background Delta-tocotrienol (δT), an isomer of vitamin E, exhibits anticancer properties in
different cancer types including non-small-cell lung cancer (NSCLC). Yet, anti-invasive …

Despite being a leading cause of death in the West, the pathophysiology of abdominal aortic
aneurysms (AAA) is still incompletely understood. Pharmacotherapy to reduce the growth of …

Lung cancer ranks as the first malignant tumor killer worldwide. Despite the knowledge that
carcinogens from tobacco smoke and the environment constitute the main causes of lung …

Rupture of abdominal aortic aneurysm (AAA) is a lethal event. No oral medicine has been
available to prevent or treat AAA. We have recently identified a novel mechanism of eNOS …

BACKGROUND: The present experiments sought to determine whether cilostazol, a
selective inhibitor of cyclic adenosine monophosphate (cAMP) phosphodiesterase 3 …

Formation of abdominal aortic aneurysms is a progressive inflammatory process that
involves infiltration and differentiation of monocytes in the vessel wall, proliferation and …