Although at the genetic level cancer is caused by diverse mutations, epigenetic
modifications are characteristic of all cancers, from apparently normal precursor tissue to …

Since its discovery in 1983, the epigenetics of human cancer has been in the shadows of
human cancer genetics. But this area has become increasingly visible with a growing …

Cancer is widely perceived as a heterogeneous group of disorders with markedly different
biological properties, which are caused by a series of clonally selected genetic changes in …

Aberrant methylation of promoter CpG islands in cancer is associated with silencing of tumor-
suppressor genes, and age-dependent hypermethylation in normal appearing mucosa may …

Changes in human DNA methylation patterns are an important feature of cancer
development and progression and a potential role in other conditions such as …

Epigenetics refers to the study of heritable changes in gene expression that occur without a
change in DNA sequence. Research has shown that epigenetic mechanisms provide an" …

Epigenetic mechanisms act to change the accessibility of chromatin to transcriptional
regulation locally and globally via modifications of the DNA and by modification or …

Purpose: P-cadherin overexpression has been reported in breast carcinomas, where it was
associated with proliferative high-grade histological tumors. This study aimed to analyze P …

Epigenetic dysregulation is central to cancer development and progression. This
dysregulation includes hypomethylation leading to oncogene activation and chromosomal …

Homocysteine-Methionine (HM) cycle produces universal methyl group donor S-
adenosylmethione (SAM), methyltransferase inhibitor S-adenosylhomocysteine (SAH) and …