A number of epidemiological studies have reported associations of β-carotene plasma
levels or intake with decreased lung cancer risk. However, intervention studies in smokers …

Background Lung cancer is one of the leading causes of malignancy in the world. Several
therapeutical and chemopreventive approaches have been practised to mitigate the …

Background This is the second update of this Cochrane Review. Some studies have
suggested a protective effect of antioxidant nutrients and higher dietary levels of fruits and …

Rationale: Lung cancer is the leading cause of cancer-related mortality in the United States.
Although supplements are used by half the population, limited information is available about …

DNA damage response (DDR) is a regulatory system responsible for maintaining genome
integrity and stability, which can sense and transduce DNA damage signals. The severity of …

There are no established chemopreventive agents for lung cancer, the leading cause of
cancer death in the United States. Prostacyclin levels are low in lung cancer and …

Gut microbiota plays a crucial role in regulating the response to immune checkpoint therapy,
therefore modulation of the microbiome with bioactive molecules like carotenoids might be a …

Background Selenium is a natural health product widely used in the treatment and
prevention of lung cancers, but large chemoprevention trials have yielded conflicting results …

Background Despite reported antiproliferative activity of vitamin A and its common use for
cancer, there is no comprehensive synthesis of its safety and efficacy in lung cancers. To …

Importance Retinitis pigmentosa (RP) is the leading cause of incurable inherited blindness
in the developed world, with an estimated prevalence of 1 in 3500 individuals. Therefore, it …