Idiopathic pulmonary fibrosis: an update on pathogenesis

Q Mei, Z Liu, H Zuo, Z Yang, J Qu - Frontiers in Pharmacology, 2022 - frontiersin.org
Idiopathic pulmonary fibrosis (IPF) is a progressive, lethal fibrotic lung disease that occurs
primarily in middle-aged and elderly adults. It is a major cause of morbidity and mortality …

[HTML][HTML] Targeting PI3K/AKT signaling for treatment of idiopathic pulmonary fibrosis

J Wang, K Hu, X Cai, B Yang, Q He, J Wang… - … Pharmaceutica Sinica B, 2022 - Elsevier
Idiopathic pulmonary fibrosis (IPF) is a chronic progressive fibrotic interstitial pneumonia
with unknown causes. The incidence rate increases year by year and the prognosis is poor …

Idiopathic pulmonary fibrosis: pathogenesis and management

G Sgalla, B Iovene, M Calvello, M Ori, F Varone… - Respiratory …, 2018 - Springer
Background Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive disease
characterized by the aberrant accumulation of fibrotic tissue in the lungs parenchyma …

Targeting oxidative stress as a therapeutic approach for idiopathic pulmonary fibrosis

C Estornut, J Milara, MA Bayarri, N Belhadj… - Frontiers in …, 2022 - frontiersin.org
Idiopathic pulmonary fibrosis (IPF) is a chronic interstitial lung disease characterized by an
abnormal reepithelialisation, an excessive tissue remodelling and a progressive fibrosis …

N-Acetylcysteine (NAC): Impacts on Human Health

MCS Tenório, NG Graciliano, FA Moura, ACM Oliveira… - Antioxidants, 2021 - mdpi.com
N-acetylcysteine (NAC) is a medicine widely used to treat paracetamol overdose and as a
mucolytic compound. It has a well-established safety profile, and its toxicity is uncommon …

The fibrotic tumor stroma

M Yamauchi, TH Barker, DL Gibbons… - The Journal of clinical …, 2018 - Am Soc Clin Investig
Intratumoral fibrosis results from the deposition of a cross-linked collagen matrix by cancer-
associated fibroblasts (CAFs). This type of fibrosis has been shown to exert mechanical …

Lycorine ameliorates bleomycin-induced pulmonary fibrosis via inhibiting NLRP3 inflammasome activation and pyroptosis

Q Liang, W Cai, Y Zhao, H Xu, H Tang, D Chen… - Pharmacological …, 2020 - Elsevier
Idiopathic pulmonary fibrosis (IPF) is a chronic and irreversible lung disease with limited
therapeutic strategies. Lycorine (LYC), an alkaloid isolated from Amaryllidaceae family …

Molecular mechanisms of pulmonary fibrogenesis and its progression to lung cancer: a review

T Kinoshita, T Goto - International journal of molecular sciences, 2019 - mdpi.com
Idiopathic pulmonary fibrosis (IPF) is defined as a specific form of chronic, progressive
fibrosing interstitial pneumonia of unknown cause, occurring primarily in older adults, and …

5-Ene-4-thiazolidinones–An efficient tool in medicinal chemistry

D Kaminskyy, A Kryshchyshyn, R Lesyk - European journal of medicinal …, 2017 - Elsevier
The presented review is an attempt to summarize a huge volume of data on 5-ene-4-
thiazolidinones being a widely studied class of small molecules used in modern organic and …

Evaluation of oxidative stress biomarkers in idiopathic pulmonary fibrosis and therapeutic applications: a systematic review

AG Fois, P Paliogiannis, S Sotgia, AA Mangoni… - Respiratory …, 2018 - Springer
Introduction Idiopathic pulmonary fibrosis (IPF), a fatal lung disease of unknown origin, is
characterized by chronic and progressive fibrosing interstitial pneumonia which …