Mammalian genomes are intricately compacted to form sophisticated 3-dimensional
structures within the tiny nucleus, so called 3D genome folding. Despite their shapes …

Cohesin, a chromatin-associated protein complex with four core subunits (Smc1a, Smc3,
Rad21 and either Stag1 or 2), has a central role in cell proliferation and gene expression in …

The regulation of cell-type-specific transcription programs is a highly controlled and complex
process that needs to be fully understood. The gene regulation is often influenced by distal …

Genome organization is intricately tied to regulating genes and associated cell fate
decisions. In this study, we examine the positioning and functional significance of human …

The functional performance of immune cells relies on a complex transcriptional regulatory
network. The three-dimensional structure of chromatin can affect chromatin status and gene …

Human genetic variation has enabled the identification of several key regulators of fetal-to-
adult hemoglobin switching, including BCL11A, resulting in therapeutic advances. However …

Cohesin is required for chromatin loop formation. However, its precise role in regulating
gene transcription remains largely unknown. We investigated the relationship between …

The co-visualization of chromatin conformation with 1D 'omics data is key to the multi-omics
driven data analysis of 3D genome organization. Chromatin contact maps are often shown …

The spatial organization of the genome modulates nuclear processes, including
transcription, replication, and DNA repair,. Eukaryotic genomes are organized into distinct …

DNA looping is vital for establishing many enhancer-promoter interactions. While CTCF is
known to anchor many cohesin-mediated loops, the looped chromatin fiber appears to …