The most enthralling and versatile class of drugs called the Non-steroidal anti-inflammatory
(NSAIDs) showed its therapeutic utility in inflammation, beginning from the era of classic …

NF-κ B activity is elevated in a high proportion of cancers, particularly advanced cancers that
have been treated previously. Cytotoxic treatment selects for such up-regulation inasmuch …

Trimellitimides 6–21 were prepared and investigated in vivo for anti-inflammatory and
ulcerogenic effects and in vitro for cytotoxicity. They were subjected to in vitro …

A new series of non-carboxylic naproxen analogues, bearing a variety of ring systems, such
as oxadiazoles 3a–c and 6a–c, cycloalkanes 4a–d, cyclic imides 5a–c, and triazoles 7–9 …

Hydrazone is a bioactive pharmacophore that can be used to design antitumor agents. We
synthesised a series of hydrazones (compounds 4–24) incorporating a 4 …

In the current work, new 1, 2, 4-triazolo [3, 4-b]-1, 3, 4-thiadiazine derivatives (1–8) were
synthesized via the ring closure reaction of 2-bromoacetophenone derivatives with 4-amino …

We hypothesized that nonsteroidal antiinflammatory drugs (NSAIDs) might enhance tumor
radiosensitivity by increasing tumor oxygenation (pO2), via either a decrease in the …

From ancient times, natural products have been continuously used as therapeutic agents in
the treatment of various ailments. Many drugs from the natural origin are available in the …

The nuclear factor of activated T cells (NFAT) transcription factors are regulated by
calcium/calcineurin signals and play important roles in T cells, muscle, bone, and neural …

Near-IR fluorescent sensitizers based on heptamethine cyanine (Cy820 and Cy820–IMC)
were synthesized and their abilities to target and abolish tumor cells via photodynamic …