[HTML][HTML] Protective functions of reactive astrocytes following central nervous system insult
M Linnerbauer, V Rothhammer - Frontiers in immunology, 2020 - frontiersin.org
Astrocytes play important roles in numerous central nervous system disorders including
autoimmune inflammatory, hypoxic, and degenerative diseases such as Multiple Sclerosis …
autoimmune inflammatory, hypoxic, and degenerative diseases such as Multiple Sclerosis …
[HTML][HTML] Sphingosine-1-phosphate: its pharmacological regulation and the treatment of multiple sclerosis: a review article
S Cohan, E Lucassen, K Smoot, J Brink, C Chen - Biomedicines, 2020 - mdpi.com
Sphingosine-1-phosphate (S1P), via its G-protein-coupled receptors, is a signaling molecule
with important regulatory properties on numerous, widely varied cell types. Five S1P …
with important regulatory properties on numerous, widely varied cell types. Five S1P …
Fingolimod suppressed the chronic unpredictable mild stress-induced depressive-like behaviors via affecting microglial and NLRP3 inflammasome activation
Y Guo, X Gan, H Zhou, H Zhou, S Pu, X Long, C Ren… - Life Sciences, 2020 - Elsevier
Depression is a common aspect of the modern lifestyle, and most patients are recalcitrant to
the current antidepressants. Fingolimod (FTY720), a sphingosine analogue approved for the …
the current antidepressants. Fingolimod (FTY720), a sphingosine analogue approved for the …
[HTML][HTML] Ablation of sphingosine kinase 2 suppresses fatty liver-associated hepatocellular carcinoma via downregulation of ceramide transfer protein
Hepatocellular carcinoma (HCC) accounts for 90% of primary liver cancer, the third leading
cause of cancer-associated death worldwide. With the increasing prevalence of metabolic …
cause of cancer-associated death worldwide. With the increasing prevalence of metabolic …
[HTML][HTML] Metabolic control of smoldering neuroinflammation
Compelling evidence exists that patients with chronic neurological conditions, which
includes progressive multiple sclerosis, display pathological changes in neural metabolism …
includes progressive multiple sclerosis, display pathological changes in neural metabolism …
Evodiamine inhibits lipopolysaccharide (LPS)-induced inflammation in BV-2 cells via regulating AKT/Nrf2-HO-1/NF-κB signaling axis
T Meng, S Fu, D He, G Hu, X Gao, Y Zhang… - Cellular and molecular …, 2021 - Springer
Neuroinflammation is caused by excessive activation of microglia and plays an essential
role in neurodegenerative diseases. After activation, microglia produce several kinds of …
role in neurodegenerative diseases. After activation, microglia produce several kinds of …
In Vitro and In Vivo Investigation of S1PR1 Expression in the Central Nervous System Using [3H]CS1P1 and [11C]CS1P1
Sphingosine-1-phosphate receptor 1 (S1PR1) is ubiquitously expressed among all tissues
and plays key roles in many physiological and cellular processes. In the central nervous …
and plays key roles in many physiological and cellular processes. In the central nervous …
[HTML][HTML] Role of sphingosine kinase in type 2 diabetes mellitus
Sphingolipids are a class of essential lipids, functioning as both cell membrane constituents
and signaling messengers. In the sphingolipid metabolic network, ceramides serve as the …
and signaling messengers. In the sphingolipid metabolic network, ceramides serve as the …
[HTML][HTML] Sphingosine 1-phoshpate receptors are located in synapses and control spontaneous activity of mouse neurons in culture
Abstract Sphingosine-1-phosphate (S1P) is best known for its roles as vascular and immune
regulator. Besides, it is also present in the central nervous system (CNS) where it can act as …
regulator. Besides, it is also present in the central nervous system (CNS) where it can act as …
[HTML][HTML] Sphingosine 1-Phosphate Lyase in the Developing and Injured Nervous System: a Dichotomy?
J Xiao - Molecular Neurobiology, 2023 - Springer
Abstract Sphingosine 1-phosphate lyase (SPL) is the terminal enzyme that controls the
degradation of the bioactive lipid sphingosine 1-phosphate (S1P) within an interconnected …
degradation of the bioactive lipid sphingosine 1-phosphate (S1P) within an interconnected …