DOACs in the anticoagulation of mechanical valves: A systematic review and future perspectives

T Langenaeken, A Vanoppen, F Janssens… - Journal of Clinical …, 2023 - mdpi.com
Valvular heart disease is a common disease often necessitating valve replacement.
Mechanical heart valves (MHVs) are often used in younger patients because of their longer …

Difference in coagulation systems of large animal species used in cardiovascular research: a systematic review

L Staelens, T Langenaeken, F Rega… - Journal of Artificial Organs, 2024 - Springer
Preclinical testing using animal models is indispensable in cardiovascular research.
However, the translation to clinical practice of these animal models is questionable since it is …

Development of an Orthotopic Pulmonary Valve Replacement Porcine Model for Mechanical Heart Valve Thrombosis Research

T Langenaeken, P De Meester, M Van Hecke, A Meuris… - 2023 - researchsquare.com
Objective Animal models play a vital role in preclinical cardiovascular testing of materials.
While sheep have traditionally served as the standard for preclinical cardiovascular testing …