This review critically summarizes the neuropathology and genetics of schizophrenia, the
relationship between them, and speculates on their functional convergence. The …

Although we have studied schizophrenia as a major disease entity over the past century, its
causes and pathogenesis remain obscure. In this article, we critically review genetic and …

Abnormalities of prefrontal cortical function are prominent features of schizophrenia and
have been associated with genetic risk, suggesting that susceptibility genes for …

Reduced fecundity, associated with severe mental disorders, places negative selection
pressure on risk alleles and may explain, in part, why common variants have not been found …

Schizophrenia is a severe mental disorder marked by hallucinations, delusions, cognitive
deficits and apathy, with a heritability estimated at 73–90%(ref.). Inheritance patterns are …

▪ Abstract A combination of genetic susceptibility and environmental perturbations appear to
be necessary for the expression of schizophrenia. In addition, the pathogenesis of the …

▪ Abstract Phenotypic variation for quantitative traits results from the segregation of alleles at
multiple quantitative trait loci (QTL) with effects that are sensitive to the genetic, sexual, and …

David A. Lewis*‡ and Jeffrey A. Lieberman†‡* Departments of Psychiatry and Neuroscience
University of Pittsburgh School of Medicine this syndrome is increased as well. Recently …

Schizophrenia is a common disorder with high heritability and a 10-fold increase in risk to
siblings of probands. Replication has been inconsistent for reports of significant genetic …

Numerous lines of inquiry implicate connectivity as a central abnormality in schizophrenia.
Myelination and factors that affect myelination, such as the function of oligodendroglia, are …