Nitric oxide (NO) is a free radical playing an important pathophysiological role in
cardiovascular and immune systems. Recent studies reported that NO levels were …

A biofilm is a community of stable microorganisms encapsulated in an extracellular matrix
produced by themselves. Many types of microorganisms that are found on living hosts or in …

The discovery of soluble GC (sGC) stimulators and sGC activators provided valuable tools to
elucidate NO–sGC signalling and opened novel pharmacological opportunities for …

The development of essential hypertension involves several factors. Vascular dysfunction,
characterized by endothelial dysfunction, low-grade inflammation and structural remodeling …

Carbon monoxide (CO) has been firmly established as an endogenous signaling molecule
with a variety of pathophysiological and pharmacological functions, including …

Pyrazole is a five-membered heterocycle bearing two adjacent nitrogen atoms. Both
pharmaceutical agents and natural products with pyrazole as a nucleus have exhibited a …

Nitric oxide (NO) signaling in biology relies on its activating cyclic guanosine
monophosphate (cGMP) production by the NO receptor soluble guanylyl cyclase (sGC). sGC …

The T cell-mediated immune response is primarily involved in the fight against infectious
diseases and cancer and its underlying mechanisms are complex. The anti-tumor T cell …

In recent years, with improvements in treatments for heart failure (HF), the survival period of
patients has been extended. However, the emergence of some patients with repeated …

Squaramides represent a class of vinylogous amides that are derived from the squarate
oxocarbon dianion. While they have been known since the 1950s, squaramides have only …