Purpose: The molecular etiology of atrial fibrillation (AF) and its treatment are poorly
understood. AF involves both electrical and structural features. Vericiguat can ameliorate …

Introduction: In 2013, riociguat a potent and specific stimulator of the soluble guanylyl
cyclase (sGC) was approved as first in class sGC stimulator which reflected a first …

Carbon monoxide (CO) as one of the three important endogenously produced signaling
molecules, termed as “gasotransmitter,” has emerged as a promising therapeutic agent for …

Background Inflammation in the central nervous system (CNS) is observed in many
neurological disorders. Nitric oxide-soluble guanylate cyclase-cyclic guanosine …

Abstract Objectives In SSc, angiogenesis impairment advances in parallel with the
development of fibrosis orchestrated by myofibroblasts originating from different sources …

Background: Clot formation on foreign surfaces of extracorporeal membrane oxygenation
systems is a frequent event. Herein, we show an approach that mimics the enzymatic …

The endogenous signaling roles of carbon monoxide (CO) have been firmly established at
the pathway level. For CO's molecular mechanism (s) of actions, hemoproteins are generally …

Nitric oxide (NO) continuously generated by healthy endothelium prevents platelet activation
and maintains vascular homeostasis. However, when artificial surfaces, like of …

Vardenafil (VDF) is a relatively new phosphodiesterase-5 inhibitor that has limited oral
bioavailability (≈ 15%). The objective of this study was to develop bilosome-based …

Nitric oxide (NO)/cyclic guanosine 3′, 5′-monophosphate (cGMP) signaling has been
shown to act as a mediator involved in pain transmission and processing. In this review, we …