Bio-enabled Engineering of Multifunctional “Living” Surfaces

DP Arnold, SC Takatori - ACS nano, 2023 - ACS Publications
Through the magic of “active matter”─ matter that converts chemical energy into mechanical
work to drive emergent properties─ biology solves a myriad of seemingly enormous …

CRISPR-Cas9-Based Gene Knockout of Immune Checkpoints in Expanded NK Cells

T Mohammadian Gol, M Kim, R Sinn… - International Journal of …, 2023 - mdpi.com
Natural killer (NK) cell immunotherapy has emerged as a novel treatment modality for
various cancer types, including leukemia. The modulation of inhibitory signaling pathways in …

Colloidal transport phenomena in dynamic, pulsating porous materials

SG Nagella, SC Takatori - AIChE Journal, 2023 - Wiley Online Library
We study the transport phenomena of colloidal particles embedded within a moving array of
obstacles that mimics a dynamic, time‐varying porous material. While colloidal transport in …

Probing macromolecular crowding at the lipid membrane interface with genetically‐encoded sensors

M Löwe, S Hänsch, E Hachani, L Schmitt… - Protein …, 2023 - Wiley Online Library
Biochemical processes within the living cell occur in a highly crowded environment, where
macromolecules, first of all proteins and nucleic acids, occupy up to 30% of the volume. The …

[HTML][HTML] In vivo affinity maturation of the HIV-1 Env-binding domain of CD4

A Pan, CC Bailey, T Ou, J Xu, X Liu, B Hu… - Research …, 2024 - ncbi.nlm.nih.gov
Many human proteins have been repurposed as biologics for clinical use. These proteins
have been engineered with in vitro techniques that improve affinity for their ligands …

Dynamic swarms regulate the morphology and distribution of soft membrane domains

A Gubbala, DP Arnold, A Jena, S Anujarerat… - arXiv preprint arXiv …, 2024 - arxiv.org
We study the dynamic structure of lipid domain inclusions embedded within a phase-
separated reconstituted lipid bilayer in contact with a swarming flow of gliding filamentous …

[引用][C] Effects of macromolecular crowding on protein targeting and translocation via SecYEG

M Löwe - 2024 - Universitäts-und Landesbibliothek …