An update on the genetics of hyperuricaemia and gout
A central aspect of the pathogenesis of gout is elevated urate concentrations, which lead to
the formation of monosodium urate crystals. The clinical features of gout result from an …
the formation of monosodium urate crystals. The clinical features of gout result from an …
[HTML][HTML] Breeding for resistance to gastrointestinal nematodes–the potential in low-input/output small ruminant production systems
The control of gastrointestinal nematodes (GIN) is mainly based on the use of drugs, grazing
management, use of copper oxide wire particles and bioactive forages. Resistance to …
management, use of copper oxide wire particles and bioactive forages. Resistance to …
[HTML][HTML] Non-parametric genetic prediction of complex traits with latent Dirichlet process regression models
Using genotype data to perform accurate genetic prediction of complex traits can facilitate
genomic selection in animal and plant breeding programs, and can aid in the development …
genomic selection in animal and plant breeding programs, and can aid in the development …
Pitfalls and remedies for cross validation with multi-trait genomic prediction methods
Incorporating measurements on correlated traits into genomic prediction models can
increase prediction accuracy and selection gain. However, multi-trait genomic prediction …
increase prediction accuracy and selection gain. However, multi-trait genomic prediction …
[HTML][HTML] Translational bioinformatics for human reproductive biology research: examples, opportunities and challenges for a future reproductive medicine
Since 1978, with the first IVF (in vitro fertilization) baby birth in Manchester (England), more
than eight million IVF babies have been born throughout the world, and many new …
than eight million IVF babies have been born throughout the world, and many new …
Cross-validation without doing cross-validation in genome-enabled prediction
Cross-validation of methods is an essential component of genome-enabled prediction of
complex traits. We develop formulae for computing the predictions that would be obtained …
complex traits. We develop formulae for computing the predictions that would be obtained …
Investigation of prediction accuracy and the impact of sample size, ancestry, and tissue in transcriptome‐wide association studies
JJ Fryett, AP Morris, HJ Cordell - Genetic epidemiology, 2020 - Wiley Online Library
In transcriptome‐wide association studies (TWAS), gene expression values are predicted
using genotype data and tested for association with a phenotype. The power of this …
using genotype data and tested for association with a phenotype. The power of this …
[HTML][HTML] GWAS findings improved genomic prediction accuracy of lipid profile traits: Tehran Cardiometabolic Genetic Study
In recent decades, ongoing GWAS findings discovered novel therapeutic modifications such
as whole-genome risk prediction in particular. Here, we proposed a method based on …
as whole-genome risk prediction in particular. Here, we proposed a method based on …
Genetic Literacy and Attitudes Survey (iGLAS): International population-wide assessment instrument
Genetics represents the fastest developing discipline in the history of scientific enquiry.
Genetic advances have implications for individuals and society, including matters related to …
Genetic advances have implications for individuals and society, including matters related to …
[HTML][HTML] Accurate prediction of maize grain yield using its contributing genes for gene-based breeding
Accurately predicting the phenotypes of complex traits is crucial to enhanced breeding in
plants and livestock, and to enhanced medicine in humans. Here we reports the first study …
plants and livestock, and to enhanced medicine in humans. Here we reports the first study …