An update on the genetics of hyperuricaemia and gout

TJ Major, N Dalbeth, EA Stahl… - Nature Reviews …, 2018 - nature.com
A central aspect of the pathogenesis of gout is elevated urate concentrations, which lead to
the formation of monosodium urate crystals. The clinical features of gout result from an …

[HTML][HTML] Breeding for resistance to gastrointestinal nematodes–the potential in low-input/output small ruminant production systems

PI Zvinorova, TE Halimani, FC Muchadeyi… - Veterinary …, 2016 - Elsevier
The control of gastrointestinal nematodes (GIN) is mainly based on the use of drugs, grazing
management, use of copper oxide wire particles and bioactive forages. Resistance to …

[HTML][HTML] Non-parametric genetic prediction of complex traits with latent Dirichlet process regression models

P Zeng, X Zhou - Nature communications, 2017 - nature.com
Using genotype data to perform accurate genetic prediction of complex traits can facilitate
genomic selection in animal and plant breeding programs, and can aid in the development …

Pitfalls and remedies for cross validation with multi-trait genomic prediction methods

D Runcie, H Cheng - G3: Genes, Genomes, Genetics, 2019 - academic.oup.com
Incorporating measurements on correlated traits into genomic prediction models can
increase prediction accuracy and selection gain. However, multi-trait genomic prediction …

[HTML][HTML] Translational bioinformatics for human reproductive biology research: examples, opportunities and challenges for a future reproductive medicine

K Liu, Y Zhang, C Martin, X Ma, B Shen - International Journal of …, 2022 - mdpi.com
Since 1978, with the first IVF (in vitro fertilization) baby birth in Manchester (England), more
than eight million IVF babies have been born throughout the world, and many new …

Cross-validation without doing cross-validation in genome-enabled prediction

D Gianola, CC Schön - G3: Genes, Genomes, Genetics, 2016 - academic.oup.com
Cross-validation of methods is an essential component of genome-enabled prediction of
complex traits. We develop formulae for computing the predictions that would be obtained …

Investigation of prediction accuracy and the impact of sample size, ancestry, and tissue in transcriptome‐wide association studies

JJ Fryett, AP Morris, HJ Cordell - Genetic epidemiology, 2020 - Wiley Online Library
In transcriptome‐wide association studies (TWAS), gene expression values are predicted
using genotype data and tested for association with a phenotype. The power of this …

[HTML][HTML] GWAS findings improved genomic prediction accuracy of lipid profile traits: Tehran Cardiometabolic Genetic Study

M Akbarzadeh, SR Dehkordi, MA Roudbar… - Scientific reports, 2021 - nature.com
In recent decades, ongoing GWAS findings discovered novel therapeutic modifications such
as whole-genome risk prediction in particular. Here, we proposed a method based on …

Genetic Literacy and Attitudes Survey (iGLAS): International population-wide assessment instrument

R Chapman, M Likhanov, F Selita… - … of Social & …, 2017 - research.gold.ac.uk
Genetics represents the fastest developing discipline in the history of scientific enquiry.
Genetic advances have implications for individuals and society, including matters related to …

[HTML][HTML] Accurate prediction of maize grain yield using its contributing genes for gene-based breeding

M Zhang, Y Cui, YH Liu, W Xu, SH Sze, SC Murray… - Genomics, 2020 - Elsevier
Accurately predicting the phenotypes of complex traits is crucial to enhanced breeding in
plants and livestock, and to enhanced medicine in humans. Here we reports the first study …