Nitric oxide (NO) is a small free radical with critical signaling roles in physiology and
pathophysiology. The generation of sufficient NO levels to regulate the resistance of the …

Evading persistent drug resistance in cancer and bacteria is quintessential to restore health
in humans, and impels intervention strategies. A distinct property of the cancer phenotype is …

Elevated intracellular reactive oxygen species (ROS) and antioxidant defense systems have
been recognized as one of the hallmarks of cancer cells. Compared with normal cells …

TRPV4 is a widely expressed cation channel of the 'transient receptor potential'(TRP) family
that is related to the vanilloid receptor VR1 (TRPV1). It functions as a Ca2+ entry channel …

Epoxyeicosatrienoic acids (EETs) are arachidonic acid metabolites that importantly
contribute to vascular and cardiac physiology. The contribution of EETs to vascular and …

The importance of reactive oxygen species (ROS) in vascular physiology and pathology is
becoming increasingly evident. All cell types in the vascular wall produce ROS derived from …

Mammalian cytochromes P450 (P450) are a family of heme-thiolate enzymes involved in the
oxidative metabolism of a variety of endogenous and exogenous lipophilic compounds …

The endothelial generation of reactive oxygen species (ROS) is important both
physiologically and in the pathogenesis of many cardiovascular disorders. ROS generated …

Neuronal activity evokes localized changes in blood flow. Although this response, termed
neurovascular coupling, is widely used to monitor human brain function and diagnose …

▪ Abstract Inflammation and infection have long been known to downregulate the activity and
expression of cytochrome P450 (CYP) enzymes involved in hepatic drug clearance. This …