Abstract PROteolysis TArgeting Chimeras (PROTACs) technology is a new protein-
degradation strategy that has emerged in recent years. It uses bifunctional small molecules …

This article reviews the molecular structure, expression pattern, physiological function,
pathological roles and molecular mechanisms of Twist1 in development, genetic disease …

Cancer is a multi-step process and requires constitutive expression/activation of
transcription factors (TFs) for growth and survival. Many of the TFs reported so far are critical …

The three homologous members of the p160 SRC family (SRC1, SRC2 and SRC3) mediate
the transcriptional functions of nuclear receptors and other transcription factors, and are the …

Cancer is characterised by uncontrolled cell division and abnormal cell growth, which is
largely caused by a variety of gene mutations. There are continuous efforts being made to …

Metastatic breast cancer is a life‐threatening stage of cancer and is the leading cause of
death in advanced breast cancer patients. Estrogen signaling and the estrogen receptor …

Twist, the basic helix-loop-helix transcription factor, is involved in the process of epithelial to
mesenchymal transitions (EMTs), which play an essential role in cancer metastasis …

Twist1, a basic helix–loop–helix transcription factor, promotes breast tumor cell epithelial–
mesenchymal transition (EMT), invasiveness, and metastasis. However, the mechanisms …

The heterogeneous breast cancers can be classified into different subtypes according to
their histopathological characteristics and molecular signatures. Foxa1 expression is linked …

Twist1 is a well-known regulator of transcription during embryonic organogenesis in many
species. In humans, Twist1 malfunction was first linked to Saethre-Chotzen syndrome and …