Virus-mediated cell-cell fusion

H Leroy, M Han, M Woottum, L Bracq… - International Journal of …, 2020 - mdpi.com
Cell-cell fusion between eukaryotic cells is a general process involved in many
physiological and pathological conditions, including infections by bacteria, parasites, and …

Consequences of HIV infection in the bone marrow niche

CL Herd, J Mellet, T Mashingaidze, C Durandt… - Frontiers in …, 2023 - frontiersin.org
Dysregulation of the bone marrow niche resulting from the direct and indirect effects of HIV
infection contributes to haematological abnormalities observed in HIV patients. The bone …

Productive HIV-1 infection of tissue macrophages by fusion with infected CD4+ T cells

R Mascarau, M Woottum, L Fromont, R Gence… - Journal of Cell …, 2023 - rupress.org
Macrophages are essential for HIV-1 pathogenesis and represent major viral reservoirs.
Therefore, it is critical to understand macrophage infection, especially in tissue …

HIV co-receptor-tropism: cellular and molecular events behind the enigmatic co-receptor switching

S Yandrapally, K Mohareer, G Arekuti… - Critical reviews in …, 2021 - Taylor & Francis
Recognition of cell-surface receptors and co-receptors is a crucial molecular event towards
the establishment of HIV infection. HIV exists as several variants that differentially recognize …

Macrophage cell-cell interactions promoting HIV-1 infection

M Dupont, QJ Sattentau - Viruses, 2020 - mdpi.com
Many pathogens infect macrophages as part of their intracellular life cycle. This is
particularly true for viruses, of which HIV-1 is one of the best studied. HIV-1 infection of …

NLRP3 is involved in long bone edification and the maturation of osteogenic cells

L Detzen, B Cheat, A Besbes, B Hassan… - Journal of cellular …, 2021 - Wiley Online Library
Overexpression of the nucleotide‐binding leucine‐rich repeat protein 3 (NLRP3)
inflammasome in chronic auto‐immune diseases leads to skeletal anomalies, with severe …

Cellular and molecular actors of myeloid cell fusion: podosomes and tunneling nanotubes call the tune

O Dufrançais, R Mascarau, R Poincloux… - Cellular and Molecular …, 2021 - Springer
Different types of multinucleated giant cells (MGCs) of myeloid origin have been described;
osteoclasts are the most extensively studied because of their importance in bone …

Mechanisms of HIV-1 cell-to-cell transfer to myeloid cells

M Han, M Woottum, R Mascarau… - Journal of Leukocyte …, 2022 - academic.oup.com
In addition to CD4+ T lymphocytes, cells of the myeloid lineage such as macrophages,
dendritic cells (DCs), and osteoclasts (OCs) are emerging as important target cells for HIV-1 …

Vpr is a VIP: HIV vpr and infected macrophages promote viral pathogenesis

J Lubow, KL Collins - Viruses, 2020 - mdpi.com
HIV infects several cell types in the body, including CD4+ T cells and macrophages. Here
we review the role of macrophages in HIV infection and describe complex interactions …

Macrophages: Key Cellular Players in HIV Infection and Pathogenesis

M Woottum, S Yan, S Sayettat, S Grinberg, D Cathelin… - Viruses, 2024 - mdpi.com
Although cells of the myeloid lineages, including tissue macrophages and conventional
dendritic cells, were rapidly recognized, in addition to CD4+ T lymphocytes, as target cells of …