Age-associated differences in the cancer molecular landscape
Cancer is an age-related disease, as incidence and mortality for most types of cancer
increase with age. However, how molecular alterations in tumors differ among patients of …
increase with age. However, how molecular alterations in tumors differ among patients of …
Oncobiology and treatment of breast cancer in young women
R Kumar, C Abreu, M Toi, S Saini, S Casimiro… - Cancer and Metastasis …, 2022 - Springer
Female breast cancer emerged as the leading cancer type in terms of incidence globally in
2020. Although mortality due to breast cancer has improved during the past three decades …
2020. Although mortality due to breast cancer has improved during the past three decades …
An integrative analysis of the age-associated multi-omic landscape across cancers
Age is the most important risk factor for cancer, as cancer incidence and mortality increase
with age. However, how molecular alterations in tumours differ among patients of different …
with age. However, how molecular alterations in tumours differ among patients of different …
Identification of aberrant luminal progenitors and mTORC1 as a potential breast cancer prevention target in BRCA2 mutation carriers
Inheritance of a BRCA2 pathogenic variant conveys a substantial life-time risk of breast
cancer. Identification of the cell (s)-of-origin of BRCA2-mutant breast cancer and targetable …
cancer. Identification of the cell (s)-of-origin of BRCA2-mutant breast cancer and targetable …
Molecular differences between younger versus older ER-positive and HER2-negative breast cancers
Abstract The RxPONDER and TAILORx trials demonstrated benefit from adjuvant
chemotherapy in patients age≤ 50 with node-positive breast cancer and Recurrence Score …
chemotherapy in patients age≤ 50 with node-positive breast cancer and Recurrence Score …
Breast-Specific Molecular Clocks Comprised of ELF5 Expression and Promoter Methylation Identify Individuals Susceptible to Cancer Initiation
A robust breast cancer prevention strategy requires risk assessment biomarkers for early
detection. We show that expression of ELF5, a transcription factor critical for normal …
detection. We show that expression of ELF5, a transcription factor critical for normal …
[HTML][HTML] Steroid Receptor Signalling in Hormone Dependent Cancers: a 5-year perspective
S Agbana, M McIlroy - The Journal of Steroid Biochemistry and Molecular …, 2024 - Elsevier
Steroid hormone receptors are key mediators in the execution of hormone action through a
combination of genomic and non-genomic action. Since their isolation and characterisation …
combination of genomic and non-genomic action. Since their isolation and characterisation …
Association Between COVID-19 and Neurological Diseases: Evidence from Large-Scale Mendelian Randomization Analysis and Single-Cell RNA Sequencing …
L Huang, Y Wang, Y He, D Huang, T Wen… - Molecular Neurobiology, 2024 - Springer
Observational studies have suggested that SARS-CoV-2 infection increases the risk of
neurological diseases, but it remains unclear whether the association is causal. The present …
neurological diseases, but it remains unclear whether the association is causal. The present …
Steroid ligands, the forgotten triggers of nuclear receptor action; implications for acquired resistance to endocrine therapy
R Bleach, SF Madden, J Hawley, S Charmsaz… - Clinical Cancer …, 2021 - AACR
Purpose: There is strong epidemiologic evidence indicating that estrogens may not be the
sole steroid drivers of breast cancer. We hypothesize that abundant adrenal androgenic …
sole steroid drivers of breast cancer. We hypothesize that abundant adrenal androgenic …
[HTML][HTML] A primer on applying AI synergistically with domain expertise to oncology
Background The concurrent growth of large-scale oncology data alongside the
computational methods with which to analyze and model it has created a promising …
computational methods with which to analyze and model it has created a promising …