Polyelectrolyte-multivalent molecule complexes: physicochemical properties and applications

SE Herrera, ML Agazzi, E Apuzzo, ML Cortez… - Soft Matter, 2023 - pubs.rsc.org
The complexation of polyelectrolytes with other oppositely charged structures gives rise to a
great variety of functional materials with potential applications in a wide spectrum of …

Pre-clinical and clinical applications of small interfering RNAs (siRNA) and co-delivery systems for pancreatic cancer therapy

S Mirzaei, MH Gholami, HL Ang, F Hashemi, A Zarrabi… - Cells, 2021 - mdpi.com
Pancreatic cancer (PC) is one of the leading causes of death and is the fourth most
malignant tumor in men. The epigenetic and genetic alterations appear to be responsible for …

[HTML][HTML] Silicified collagen scaffold induces semaphorin 3A secretion by sensory nerves to improve in-situ bone regeneration

YX Ma, K Jiao, QQ Wan, J Li, MY Liu, ZB Zhang, W Qin… - Bioactive Materials, 2022 - Elsevier
Sensory nerves promote osteogenesis through the release of neuropeptides. However, the
potential application and mechanism in which sensory nerves promote healing of bone …

Liquid crystalline nanoparticles enable a multifunctional approach for topical psoriasis therapy by co-delivering triptolide and siRNAs

AVP Silvestrini, FG Praça, MN Leite… - International Journal of …, 2023 - Elsevier
Liquid crystalline nanoparticles (LCNs) are an attractive drugs topical delivery system due to
the great internal ordering, wide interfacial area and structural similarities with the skin. In …

Delivery of miR-320a-3p by gold nanoparticles combined with photothermal therapy for directly targeting Sp1 in lung cancer

J Peng, R Wang, W Sun, M Huang, R Wang, Y Li… - Biomaterials …, 2021 - pubs.rsc.org
Lung cancer is the second most common tumor and has the highest mortality rate. Both
novel therapeutic targets and approaches are needed to improve the overall survival of …

Degradation of drug delivery nanocarriers and payload release: A review of physical methods for tracing nanocarrier biological fate

PM Perrigue, RA Murray, A Mielcarek, A Henschke… - Pharmaceutics, 2021 - mdpi.com
Nanoformulations offer multiple advantages over conventional drug delivery, enhancing
solubility, biocompatibility, and bioavailability of drugs. Nanocarriers can be engineered with …

Shining light on polymeric drug nanocarriers with fluorescence correlation spectroscopy

S Schmitt, L Nuhn, M Barz, HJ Butt… - Macromolecular Rapid …, 2022 - Wiley Online Library
The use of nanoparticles as carriers is an extremely promising way for administration of
therapeutic agents, such as drug molecules, proteins, and nucleic acids. Such nanocarriers …

Layer-by-Layer technique as a versatile tool for gene delivery applications

DS Linnik, YV Tarakanchikova, MV Zyuzin… - Expert Opinion on …, 2021 - Taylor & Francis
Introduction: Gene therapy is a breakthrough medical field which focuses on the therapeutic
delivery of recombinant nucleic acids in order to treat or prevent a broad spectrum of …

Positron Emission Tomography Studies of the Biodistribution, Translocation, and Fate of Poly Allyl Amine‐Based Carriers for Sirna Delivery by Systemic and …

C Simo, C Salvador, P Andreozzi, V Gomez‐Vallejo… - Small, 2023 - Wiley Online Library
Polyamine‐based vectors offer many advantages for gene therapy, but they are hampered
by a limited knowledge on their biological fate and efficacy for nucleic acid delivery. The 18F …

Poly (allylamine)-tripolyphosphate Ionic Assemblies as Nanocarriers: Friend or Foe?

E Apuzzo, M Agazzi, SE Herrera, A Picco… - ACS Applied Bio …, 2023 - ACS Publications
Designing effective drug nanocarriers that are easy to synthesize, robust, and nontoxic is a
significant challenge in nanomedicine. Polyamine-multivalent molecule nanocomplexes are …