Shigella comprises four species of human-restricted pathogens causing bacillary dysentery.
While Shigella possesses multiple genetic loci contributing to virulence, a type III secretion …

Live bacteria, including attenuated bacteria and probiotics, can be engineered to deliver
target antigen to excite the host immune system. The preponderance of these live bacterial …

ABSTRACT The native Invaplex (InvaplexNAT) vaccine and adjuvant is an ion exchange-
purified product derived from the water extract of virulent Shigella species. The key …

Strain-promoted azide–alkyne cycloaddition (SPAAC) reactions like click chemistry have the
potential to be highly scalable, robust, and cost-effective methods for generating small-and …

Shigellosis, caused by the bacteria Shigella, is the leading cause of bacterial diarrhea and
the second leading cause of diarrheal death among children under the age of five …

With the acquirement of antibiotic resistance, Shigella has resulted in multiple epidemics of
shigellosis, an infectious diarrheal disease, causing thousands of deaths per year …

Background No commercial vaccines are available against drug-resistant Shigella due to
serotype-specific/narrow-range of protection. Nanoparticle-based biomimetic vaccines …

The Shigella artificial invasin complex (InvaplexAR) vaccine is a subunit approach that
effectively induces robust immunogenicity directed to serotype-specific lipopolysaccharide …

Despite the results from zebrafish challenged model have demonstrated that Listeria
monocytogenes (Lm) has strong adjuvant effects when this attenuated pathogenic bacteria …

Some Gram-negative bacteria utilize type III secretion system (T3SS) as a tool in their
arsenal in the pursuit of host invasion. The T3SS works to the advantage of the pathogen …