A comprehensive proteomic SWATH-MS workflow for profiling blood extracellular vesicles: a new avenue for glioma tumour surveillance

S Hallal, A Azimi, H Wei, N Ho, MYT Lee… - International journal of …, 2020 - mdpi.com
Improving outcomes for diffuse glioma patients requires methods that can accurately and
sensitively monitor tumour activity and treatment response. Extracellular vesicles (EV) are …

Deep sequencing of small RNAs from neurosurgical extracellular vesicles substantiates miR-486-3p as a circulating biomarker that distinguishes glioblastoma from …

S Hallal, S Ebrahim Khani, H Wei, MYT Lee… - International journal of …, 2020 - mdpi.com
Extracellular vesicles (EVs) play key roles in glioblastoma (GBM; astrocytoma grade IV)
biology and are novel sources of biomarkers. EVs released from GBM tumors can cross the …

Chaperonins in cancer: Expression, function, and migration in extracellular vesicles

AJL Macario, EC de Macario - Seminars in Cancer Biology, 2022 - Elsevier
The chaperonins CCT and Hsp60 are molecular chaperones, members of the chaperone
system (CS). Chaperones are cytoprotective but if abnormal in quantity or quality they may …

Extracellular heat shock proteins in cancer: From early diagnosis to new therapeutic approach

CC Bavisotto, AM Gammazza, C Campanella… - Seminars in Cancer …, 2022 - Elsevier
In cancer, human cells lose the ability to properly control the series of events that occur
constantly during cell growth and division, including protein expression, stability, and …

Extracellular vesicles as source for the identification of minimally invasive molecular signatures in glioblastoma

E Rackles, PH Lopez, JM Falcon-Perez - Seminars in Cancer Biology, 2022 - Elsevier
The analysis of extracellular vesicles (EVs) as a source of cancer biomarkers is an emerging
field since low-invasive biomarkers are highly demanded. EVs constitute a heterogeneous …

Upregulation of CCT-3 induces breast cancer cell proliferation through miR-223 competition and Wnt/β-catenin signaling pathway activation

H Qu, F Zhu, H Dong, X Hu, M Han - Frontiers in oncology, 2020 - frontiersin.org
The clinical significance and the function of chaperonin-containing TCP1 complex 3 (CCT-3)
in breast cancer remain unknown. In this study, we found that CCT-3 was markedly …

Identification of crucial candidate genes and pathways in glioblastoma multiform by bioinformatics analysis

AM Alshabi, B Vastrad, IA Shaikh, C Vastrad - Biomolecules, 2019 - mdpi.com
The present study aimed to investigate the molecular mechanisms underlying glioblastoma
multiform (GBM) and its biomarkers. The differentially expressed genes (DEGs) were …

CCT6A and CHCHD2 are coamplified with EGFR and associated with the unfavorable clinical outcomes of lung adenocarcinoma

H Wang, X Wang, L Xu, Y Lin, J Zhang - Disease markers, 2022 - Wiley Online Library
Chaperonin containing TCP1 subunit 6A (CCT6A) and coiled‐coil‐helix‐coiled‐coil‐helix
domain containing 2 (CHCHD2) are located at the chromosome 7p11 region proximal to …

HOXB2 increases the proliferation and invasiveness of colon cancer cells through the upregulation of CCT6A

X Yang, Y Tong, W Ye, L Chen - Molecular Medicine …, 2022 - spandidos-publications.com
Colon cancer has a high mortality rate, thus there is an urgent need to develop novel
therapeutic options for clinical management of the disease. Studies have revealed that …

Targeting heat shock proteins in Malignant brain tumors: from basic research to clinical trials

A Babi, K Menlibayeva, T Bex, A Doskaliev… - Cancers, 2022 - mdpi.com
Simple Summary Heat shock proteins (HSPs) play an important role in cellular metabolism
and therefore are highly expressed in malignant brain tumors. In the current review, the …