A comprehensive proteomic SWATH-MS workflow for profiling blood extracellular vesicles: a new avenue for glioma tumour surveillance
Improving outcomes for diffuse glioma patients requires methods that can accurately and
sensitively monitor tumour activity and treatment response. Extracellular vesicles (EV) are …
sensitively monitor tumour activity and treatment response. Extracellular vesicles (EV) are …
Deep sequencing of small RNAs from neurosurgical extracellular vesicles substantiates miR-486-3p as a circulating biomarker that distinguishes glioblastoma from …
S Hallal, S Ebrahim Khani, H Wei, MYT Lee… - International journal of …, 2020 - mdpi.com
Extracellular vesicles (EVs) play key roles in glioblastoma (GBM; astrocytoma grade IV)
biology and are novel sources of biomarkers. EVs released from GBM tumors can cross the …
biology and are novel sources of biomarkers. EVs released from GBM tumors can cross the …
Chaperonins in cancer: Expression, function, and migration in extracellular vesicles
AJL Macario, EC de Macario - Seminars in Cancer Biology, 2022 - Elsevier
The chaperonins CCT and Hsp60 are molecular chaperones, members of the chaperone
system (CS). Chaperones are cytoprotective but if abnormal in quantity or quality they may …
system (CS). Chaperones are cytoprotective but if abnormal in quantity or quality they may …
Extracellular heat shock proteins in cancer: From early diagnosis to new therapeutic approach
CC Bavisotto, AM Gammazza, C Campanella… - Seminars in Cancer …, 2022 - Elsevier
In cancer, human cells lose the ability to properly control the series of events that occur
constantly during cell growth and division, including protein expression, stability, and …
constantly during cell growth and division, including protein expression, stability, and …
Extracellular vesicles as source for the identification of minimally invasive molecular signatures in glioblastoma
E Rackles, PH Lopez, JM Falcon-Perez - Seminars in Cancer Biology, 2022 - Elsevier
The analysis of extracellular vesicles (EVs) as a source of cancer biomarkers is an emerging
field since low-invasive biomarkers are highly demanded. EVs constitute a heterogeneous …
field since low-invasive biomarkers are highly demanded. EVs constitute a heterogeneous …
Upregulation of CCT-3 induces breast cancer cell proliferation through miR-223 competition and Wnt/β-catenin signaling pathway activation
H Qu, F Zhu, H Dong, X Hu, M Han - Frontiers in oncology, 2020 - frontiersin.org
The clinical significance and the function of chaperonin-containing TCP1 complex 3 (CCT-3)
in breast cancer remain unknown. In this study, we found that CCT-3 was markedly …
in breast cancer remain unknown. In this study, we found that CCT-3 was markedly …
Identification of crucial candidate genes and pathways in glioblastoma multiform by bioinformatics analysis
AM Alshabi, B Vastrad, IA Shaikh, C Vastrad - Biomolecules, 2019 - mdpi.com
The present study aimed to investigate the molecular mechanisms underlying glioblastoma
multiform (GBM) and its biomarkers. The differentially expressed genes (DEGs) were …
multiform (GBM) and its biomarkers. The differentially expressed genes (DEGs) were …
CCT6A and CHCHD2 are coamplified with EGFR and associated with the unfavorable clinical outcomes of lung adenocarcinoma
H Wang, X Wang, L Xu, Y Lin, J Zhang - Disease markers, 2022 - Wiley Online Library
Chaperonin containing TCP1 subunit 6A (CCT6A) and coiled‐coil‐helix‐coiled‐coil‐helix
domain containing 2 (CHCHD2) are located at the chromosome 7p11 region proximal to …
domain containing 2 (CHCHD2) are located at the chromosome 7p11 region proximal to …
HOXB2 increases the proliferation and invasiveness of colon cancer cells through the upregulation of CCT6A
X Yang, Y Tong, W Ye, L Chen - Molecular Medicine …, 2022 - spandidos-publications.com
Colon cancer has a high mortality rate, thus there is an urgent need to develop novel
therapeutic options for clinical management of the disease. Studies have revealed that …
therapeutic options for clinical management of the disease. Studies have revealed that …
Targeting heat shock proteins in Malignant brain tumors: from basic research to clinical trials
Simple Summary Heat shock proteins (HSPs) play an important role in cellular metabolism
and therefore are highly expressed in malignant brain tumors. In the current review, the …
and therefore are highly expressed in malignant brain tumors. In the current review, the …