TCP1, one of the subunits of molecular chaperone containing tailless complex polypeptide 1
(CCT)(CCT1), maybe play an essential role in cell proliferation and tumorigenesis. However …

En un primer momento, los procesos de envejecimiento y cáncer podrían parecer opuestos.
Sin embargo, el hecho de que compartan tanto la acumulación del daño celular como …

Recent therapeutic advances have improved the survival of head and neck squamous cell
carcinoma (HNSCC) patients, but the prognosis of HNSCC remains dismal. Further …

There have been limited improvements in diagnosis, treatment, and outcomes of primary
brain cancers, including glioblastoma, over the past 10 years. This is largely attributable to …

In the post-genome wide association study era, an important objective is developing a more
comprehensive understanding of the biological mechanisms through which genetic variants …

The 90-kDa heat shock proteins (HSP90s) are molecular chaperones essential for folding,
unfolding, degradation and activity of a wide range of client proteins. HSP90s and their …

Wilms tumor is a common abdominal malignant tumor in children. However, the molecular
mechanism of Wilms tumor is unclear. GSE66405 and GSE197047 were obtained from the …

Cellular health is dependent on the proper folding of proteins and dysregulation of this
pathway can lead to many diseases including neurodegeneration and cancer. This thesis …