NAD+ was discovered during yeast fermentation, and since its discovery, its important roles
in redox metabolism, aging, and longevity, the immune system and DNA repair have been …

Acute lymphoblastic leukemia (ALL) is a cancer-specific lymphoid cell. Induction and
consolidation chemotherapy alone or in combination with different therapeutic approaches …

In spite of the remarkable progress in basic and preclinical studies of acute myeloid
leukemia (AML), the five-year survival rate of AML patients remains poor, highlighting the …

CD38 (Cluster of Differentiation 38) is a multifunctional ecto-enzyme that metabolizes NAD+
and mediates nicotinamide dinucleotide (NAD+) and extracellular nucleotide homeostasis …

Despite the high remission rates achieved using T cells bearing a chimeric antigen receptor
(CAR) against hematogical malignancies, there is still a considerable proportion of patients …

Multiple myeloma (MM) is a plasma cell neoplasm that commonly expresses CD38.
Daratumumab (DARA), a human monoclonal antibody targeting CD38, has significantly …

There is a strong biological rationale for the augmentation of allogeneic natural killer (NK)
cell therapies with a chimeric antigen receptor (CAR) to enhance acute myeloid leukemia …

Many hematologic malignancies are not curable with chemotherapy and require novel
therapeutic approaches. Chimeric antigen receptor (CAR) T-cell therapy is 1 such approach …

High-risk childhood leukemia has a poor prognosis because of treatment failure and toxic
side effects of therapy. Drug encapsulation into liposomal nanocarriers has shown clinical …

Protein biogenesis, maturation and degradation are tightly regulated processes that are
governed by a complex network of signaling pathways. The endoplasmic reticulum (ER) is …