Depression is a worldwide disease causing severe disability, morbidity, and mortality.
Despite abundant studies, the precise mechanisms underlying the pathophysiology of …

The gut microbiota is critical for maintaining human health and the immunological system.
Several neuroscientific studies have shown the significance of microbiota in developing …

The α7 subtype of the nicotinic acetylcholine receptor (α7 nAChR: coded by Chrna7) is
known to regulate the cholinergic ascending anti-inflammatory pathway. We previously …

Gut microbiota dysbiosis has recently been reported in a number of clinical states, including
neurological, psychiatric, cardiovascular, metabolic and autoimmune disorders. Yet, it is not …

Neuroinflammation plays a key role in the pathogenesis of major depressive disorder
(MDD), including treatment-resistant depression (TRD). Patients with TRD have higher …

Osteoporosis is a systemic skeletal disease characterized by decreased bone mass,
destruction of bone microstructure, raised bone fragility, and enhanced risk of fractures. The …

The pathologies of many diseases are influenced by environmental temperature. As early as
the classical Roman age, people believed that exposure to cold weather was bad for …

The microbiota-gut-brain axis is a bidirectional regulatory pathway between the brain and
the gastrointestinal tract, which plays an important role in maintain homeostasis. Gut …

Introduction Recent studies have highlighted the vital role of gut microbiota in traumatic
brain injury (TBI). Fecal microbiota transplantation (FMT) is an effective means of regulating …

Autoimmune diseases (AIDs) are a series of immune-mediated lethal diseases featured by
over-activated immune cells attacking healthy self-tissues and organs due to the loss of …