Precision medicine and phenotypes, endotypes, genotypes, regiotypes, and theratypes of allergic diseases

I Agache, CA Akdis - The Journal of clinical investigation, 2019 - Am Soc Clin Investig
A rapidly developing paradigm for modern health care is a proactive and individualized
response to patients' symptoms, combining precision diagnosis and personalized treatment …

Genomic predictors of asthma phenotypes and treatment response

N Hernandez-Pacheco, M Pino-Yanes… - Frontiers in …, 2019 - frontiersin.org
Asthma is a complex respiratory disease considered as the most common chronic condition
in children. A large genetic contribution to asthma susceptibility is predicted by the clustering …

[HTML][HTML] An update on the prevalence, chronicity, and severity of atopic dermatitis and the associated epidemiological risk factors in the Singapore/Malaysia Chinese …

JJ Lim, YYE Lim, JY Ng, P Malipeddi, YT Ng… - World Allergy …, 2022 - Elsevier
Abstract Background Atopic Dermatitis (AD) is a highly pruritic, chronic-recurrent
inflammatory skin condition associated with erythematous lesions that affect a significant …

Genome‐wide association study of inhaled corticosteroid response in admixed children with asthma

N Hernandez‐Pacheco, N Farzan… - Clinical & …, 2019 - Wiley Online Library
Background Inhaled corticosteroids (ICS) are the most widely prescribed and effective
medication to control asthma symptoms and exacerbations. However, many children still …

Pharmacogenetics of inhaled long‐acting beta2‐agonists in asthma: a systematic review

EMA Slob, SJH Vijverberg, CNA Palmer… - Pediatric Allergy and …, 2018 - Wiley Online Library
Background Long‐acting beta2‐agonists (LABA) are recommended in asthma therapy;
however, not all asthma patients respond well to LABA. We performed a systematic review …

Genetic associations of the response to inhaled corticosteroids in asthma: a systematic review

O Keskin, N Farzan, E Birben, H Akel… - Clinical and …, 2019 - Wiley Online Library
There is wide variability in the response to inhaled corticosteroids (ICS) in asthma. While
some of this heterogeneity of response is due to adherence and environmental causes …

What did we learn from multiple omics studies in asthma?

O Ivanova, LB Richards, SJ Vijverberg, AH Neerincx… - Allergy, 2019 - Wiley Online Library
More than a decade has passed since the finalization of the Human Genome Project. Omics
technologies made a huge leap from trendy and very expensive to routinely executed and …

Genome-wide association study of asthma exacerbations despite inhaled corticosteroid use

N Hernandez-Pacheco, SJ Vijverberg… - European …, 2021 - Eur Respiratory Soc
Rationale Substantial variability in response to asthma treatment with inhaled corticosteroids
(ICS) has been described among individuals and populations, suggesting the contribution of …

Treatment response heterogeneity in asthma: the role of genetic variation

SJH Vijverberg, N Farzan, EMA Slob… - Expert review of …, 2018 - Taylor & Francis
Introduction: Asthmatic patients show a large heterogeneity in response to asthma
medication. Rapidly evolving genotyping technologies have led to the identification of …

Pharmacogenetics of pediatric asthma: current perspectives

J Perez-Garcia, A Espuela-Ortiz… - Pharmacogenomics …, 2020 - Taylor & Francis
Asthma is a chronic respiratory disease that affects 339 million people worldwide and has a
considerable impact on the pediatric population. Asthma symptoms can be controlled by …