The innate biologies of adaptive antigen receptors

AC Hayday, P Vantourout - Annual Review of Immunology, 2020 - annualreviews.org
Nonclonal innate immune responses mediated by germ line–encoded receptors, such as
Toll-like receptors or natural killer receptors, are commonly contrasted with diverse …

[HTML][HTML] Binding of staphylococcal enterotoxin B (SEB) to B7 receptors triggers TCR-and CD28-mediated inflammatory signals in the absence of MHC class II …

M Kunkl, C Amormino, S Caristi, V Tedeschi… - Frontiers in …, 2021 - frontiersin.org
The inflammatory activity of staphylococcal enterotoxin B (SEB) relies on its capacity to
trigger polyclonal T-cell activation by binding both T-cell receptor (TCR) and costimulatory …

[HTML][HTML] Staphylococcal and streptococcal superantigens trigger B7/CD28 costimulatory receptor engagement to hyperinduce inflammatory cytokines

A Popugailo, Z Rotfogel, E Supper, D Hillman… - Frontiers in …, 2019 - frontiersin.org
Staphylococcal and streptococcal superantigens are virulence factors that cause toxic shock
by hyperinducing inflammatory cytokines. Effective T-cell activation requires interaction …

[HTML][HTML] Binding of catechins to staphylococcal enterotoxin A

Y Shimamura, M Utsumi, C Hirai, S Nakano, S Ito… - Molecules, 2018 - mdpi.com
Staphylococcal enterotoxin A (SEA) is a toxin protein, and is the most common cause of
staphylococcal food poisoning. Polyphenols, such as catechins, are known to interact with …

[HTML][HTML] Targeting staphylococcal enterotoxin B binding to CD28 as a new strategy for dampening superantigen-mediated intestinal epithelial barrier dysfunctions

C Amormino, E Russo, V Tedeschi, MT Fiorillo… - Frontiers in …, 2024 - frontiersin.org
Staphylococcus aureus is a gram-positive bacterium that may cause intestinal inflammation
by secreting enterotoxins, which commonly cause food-poisoning and gastrointestinal …

The intracellular helical bundle of human glucose transporter GLUT4 is important for complex formation with ASPL

P Huang, H Åbacka, D Varela, R Venskutonytė… - FEBS Open …, 2023 - Wiley Online Library
Glucose transporters (GLUTs) are responsible for transporting hexose molecules across
cellular membranes. In adipocytes, insulin stimulates glucose uptake by redistributing …

[HTML][HTML] Bivalent binding of staphylococcal superantigens to the TCR and CD28 triggers inflammatory signals independently of antigen presenting cells

M Kunkl, C Amormino, F Spallotta, S Caristi… - Frontiers in …, 2023 - frontiersin.org
Staphylococcus aureus superantigens (SAgs) such as staphylococcal enterotoxin A (SEA)
and B (SEB) are potent toxins stimulating T cells to produce high levels of inflammatory …

Putative staphylococcal enterotoxin possesses two common structural motifs for MHC-II binding

S Rahman, S Saha, SB Dasgupta, AK Das - International Journal of …, 2024 - Elsevier
Staphylococcus aureus has become a significant cause of health risks in humankind.
Staphylococcal superantigens (SAgs) or enterotoxins are the key virulent factors that can …

Analyses of the complex formation of staphylococcal enterotoxin A and the human gp130 cytokine receptor

S Uzunçayır, A Vera‐Rodriguez, P Regenthal… - FEBS …, 2022 - Wiley Online Library
Superantigens (SAgs) are bacterial enterotoxins produced by Staphylococcus aureus.
Staphylococcal enterotoxin type A (SEA), a staphylococcal superantigen, has been shown to …

[HTML][HTML] 金黄色葡萄球菌类肠毒素W 的超抗原活性位点预测与克隆表达

杨玉花, 库鑫, 宫雅楠, 孟凡亮, 卜东波, 郭亚慧… - 中华流行病学 …, 2023 - html.rhhz.net
目的预测金黄色葡萄球菌类肠毒素W (SElW) 与T 细胞受体(TCR) 的对接和超抗原活性位点,
并对SElW 进行克隆表达和纯化. 方法利用AlphaFold 对SElW 蛋白单体进行三维结构预测 …