T-helper cells and their cytokines in pathogenesis and treatment of asthma

T Ji, H Li - Frontiers in Immunology, 2023 - frontiersin.org
Prosperous advances in understanding the cellular and molecular mechanisms of chronic
inflammation and airway remodeling in asthma have been made over the past several …

Vernal Keratoconjunctivitis: Immunopathological Insights and Therapeutic Applications of Immunomodulators

NK Hehar, DGI Chigbu - Life, 2024 - mdpi.com
Vernal keratoconjunctivitis (VKC) is a complex and multifactorial disease process that
employs Th2 cell-mediated immunologic processes, which involves the overexpression of …

Exogenous IL-25 ameliorates airway neutrophilia via suppressing macrophage M1 polarization and the expression of IL-12 and IL-23 in asthma

C Chang, G Chen, W Wu, D Chen, S Chen, J Gao… - Respiratory …, 2023 - Springer
Background Severe asthma is associated with substantial mortality and has unmet
therapeutic need. A subset of severe asthma is characterized by neutrophilic airway …

Daqing formula ameliorated allergic asthma and airway dysbacteriosis in mice challenged with ovalbumin and ampicillin

L Wu, QY Peng, XJ Li, MY Guo, JQ He, HZ Ying… - Journal of …, 2024 - Elsevier
Ethnopharmacological relevance Asthma is a chronic airway inflammatory disease that can
lead to several complications caused by bacterial infections. However, recurrent attacks of …

树突状细胞在过敏性哮喘发病中的作用及机制研究新进展.

张芸蔓, 黄功华, 王妍妍 - Journal of Practical Medicine …, 2023 - search.ebscohost.com
过敏性哮喘是一种针对无害空气过敏原发生的以Th2 细胞过度激活为特征的气道慢性炎症性
疾病, 其发病率高且易反复发作, 严重危害人类健康. 近年来研究表明树突状细胞(dendritic cell …

[HTML][HTML] Modulating Th1/Th2 drift in asthma-related immune inflammation by enhancing bone mesenchymal stem cell homing through targeted inhibition of the Notch1 …

W Kun, C Xiaomei, Y Lei, Z Huizhi - International Immunopharmacology, 2024 - Elsevier
Asthma, a disease intricately linked to immune inflammation, is significantly influenced by
the immune regulatory effect of bone mesenchymal stem cells (BMSCs). This study aims to …

Clinical Remission Criteria and Serum Levels of Type 2 Inflammation Mediators during 24 Weeks of Treatment with the Anti-IL-5 Drug Mepolizumab in Patients with T2 …

J Palacionyte, A Januskevicius, E Vasyle, A Rimkunas… - Diagnostics, 2024 - mdpi.com
Anti-interleukin (IL) 5 is an effective treatment modality for inhibiting eosinophilic
inflammation in patients with T2-high severe asthma. The aim of this study was to determine …

Deciphering the Immune Subtypes and Signature Genes: A Novel Approach Towards Diagnosing and Prognosticating Severe Asthma through Interpretable Machine …

W Tang, Y Hu, Y Lin, B Peng, C Xiang - bioRxiv, 2024 - biorxiv.org
Asthma, a pervasive pulmonary disorder, affects countless individuals globally.
Characterized by chronic inflammation of the bronchial passages, its symptoms include …

Neuron-dependent tuft cell expansion initiates sinonasal allergic Type 2 inflammation

JF Ortiz-Carpena, JM Inclan-Rico, MB Weiner… - bioRxiv, 2023 - biorxiv.org
It is unknown whether interactions between tuft cells and trigeminal sinonasal neurons
contribute to allergic disease. Intranasal administration of house dust mite or fungal …

心脏淀粉样变性与心房颤动的关系及发病机制的研究进展.

吴博, 赖珩莉, 沈国旺, 陈震寰… - Journal of Practical …, 2023 - search.ebscohost.com
心脏淀粉样变性(cardiac amyloidosis, CA) 是一种由错误折叠的淀粉样蛋白在心肌细胞外沉积
引起的心肌病. CA 与较高的心房颤动(atrial fibrillation, AF) 患病率相关, 心肌淀粉样蛋白浸润可 …