Microfluidic organs and organoids-on-a-chip models of human gastrointestinal systems
have been established to recreate adequate microenvironments to study physiology and …

Drug development is a time-consuming and expensive process, given the low success rate
of clinical trials. Now, anticancer drug developments have shifted to three-dimensional (3D) …

Advances in three-dimensional (3D) cell culture technology have led to the development of
more biologically and physiologically relevant models to study organ development, disease …

Background Colorectal cancer (CRC) is a common malignancy that can significantly
diminish patients' quality of life. Astragalus mongholicus Bunge-Curcuma aromatica …

Abnormal glycerophospholipid (GPL) metabolism represented by phosphatidylcholine (PC)
and phosphatidylethanolamine (PE) has been as a universal metabolic hallmark of cancer …

To better understand a role of eIF4E S209 in oncogenic translation, we generated
EIF4ES209A/+ heterozygous knockin (4EKI) HCT 116 human colorectal cancer (CRC) cells …

Simple Summary Amino acid transporters play a multifaceted role in tumor initiation,
progression, and therapy resistance. They are critical to cover the high energetic and …

Cancer remains a leading health burden worldwide. One of the challenges hindering cancer
therapy development is the substantial discrepancies between the existing cancer models …

Engineered biomaterial scaffolds are becoming more prominent in research laboratories to
study drug efficacy for oncological applications in vitro, but do they have a place in …

Simple Summary Given ongoing issues with public opinion against the use of animals in
biomedical research, scant research resources, high drug costs, low translational success …